Pilot evaluation of short-term changes in macular pigment and retinal sensitivity in different phenotypes of early age-related macular degeneration after carotenoid supplementation

F Corvi, EH Souied, Y Falfoul, A Georges, C Jung, L Querques, G Querques

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose To investigate the response of carotenoid supplementation in different phenotypes of early agerelated macular degeneration (AMD) by measuring macular pigment optical density (MPOD) and retinal sensitivity. Methods Consecutive patients with only medium/large drusen and only reticular pseudodrusen (RPD) and agematched and sex-matched controls were enrolled. At baseline, participants underwent a complete ophthalmological examination including measurement of best-corrected visual acuity (BCVA), MPOD and retinal sensitivity. Patients were put on vitamin supplementation (lutein 10 mg/day, zeaxanthin 2 mg/day) and 3 months later underwent a repeated ophthalmological examination. Results Twenty patients with medium/large drusen, 19 with RPD and 15 control subjects were included. At baseline, in controls, mean MPOD and BCVA were significantly higher compared with RPD (p=0.001 and p=0.01) but similar to medium/large drusen (p=0.9 and p=0.4). Mean retinal sensitivity was significantly higher in controls compared with RPD and medium/large drusen (for all p
Original languageEnglish
Pages (from-to)770-773
Number of pages4
JournalBritish Journal of Ophthalmology
Volume101
Issue number6
DOIs
Publication statusPublished - 2017

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