Pineal graft in old rats improves erythrocyte resistance to peroxyl radical-induced hemolysis

Fausto Moroni, Fiorella Marcheselli, Rina Recchioni, Patrizia Fattoretti, Carlo Bertoni-Freddari

Research output: Contribution to journalArticlepeer-review

Abstract

Pineal graft from young to old rats was performed and red blood cell hemolysis, induced by the water-soluble radical initiator 2,2′-azobis (2-amidino-propane) dihydrochloride (AAPH), was evaluated 6 months after graft. Pineal graft modified the hemolysis curve kinetic profile: in grafted rats versus age-matched controls, the 50% hemolysis time as well as the lag time were longer, whereas the maximal amount of hemolysis was lower, and it occurred over a longer period of time. Thiobarbituric acid reactive substances production was lower in pineal-grafted rats than in controls and the age-related decrease of erythrocyte membrane fluidity was prevented by pineal graft. The present findings support an important physiological role of pineal gland in preventing age-related alterations of erythrocyte membranes and suggest a possible antioxidant action of melatonin.

Original languageEnglish
Pages (from-to)339-344
Number of pages6
JournalBiogerontology
Volume5
Issue number5
DOIs
Publication statusPublished - 2004

Keywords

  • Aging
  • Hemolysis
  • Melatonin
  • Peroxyl radicals
  • Pineal graft
  • TBARS

ASJC Scopus subject areas

  • Geriatrics and Gerontology

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