Abstract
Cancer is among the leading causes of death worldwide. Several pharmacological protocols have been developed in order to block tumor progression often showing partial efficacy and severe counterproductive effects. It is now conceived that a healthy lifestyle coupled with the consumption of certain phytochemicals can play a protective role against tumor development and progression. According to this vision, it has been introduced the concept of “chemoprevention”. This term refers to natural agents with the capability to interfere with the tumorigenesis and metastasis, or at least, attenuate the cancer-related symptoms. Piperine (1-Piperoylpiperidine), a main extract of Piper longum and Piper nigrum, is an alkaloid with a long history of medicinal use. In fact, it exhibits a variety of biochemical and pharmaceutical properties, including chemopreventive activities without significant cytotoxic effects on normal cells, at least at doses < of 250 µg/ml. The aim of this review is to discuss the relevant molecular and cellular mechanisms underlying the chemopreventive action of this natural alkaloid.
| Original language | English |
|---|---|
| Journal | Molecular Biology Reports |
| DOIs | |
| Publication status | Accepted/In press - Jan 1 2019 |
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Keywords
- Cancer therapy
- Chemoprevention
- Natural compounds
- Piperine
ASJC Scopus subject areas
- Molecular Biology
- Genetics
Cite this
Piperine : role in prevention and progression of cancer. / Zadorozhna, Mariia; Tataranni, Tiziana; Mangieri, Domenica.
In: Molecular Biology Reports, 01.01.2019.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Piperine
T2 - role in prevention and progression of cancer
AU - Zadorozhna, Mariia
AU - Tataranni, Tiziana
AU - Mangieri, Domenica
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Cancer is among the leading causes of death worldwide. Several pharmacological protocols have been developed in order to block tumor progression often showing partial efficacy and severe counterproductive effects. It is now conceived that a healthy lifestyle coupled with the consumption of certain phytochemicals can play a protective role against tumor development and progression. According to this vision, it has been introduced the concept of “chemoprevention”. This term refers to natural agents with the capability to interfere with the tumorigenesis and metastasis, or at least, attenuate the cancer-related symptoms. Piperine (1-Piperoylpiperidine), a main extract of Piper longum and Piper nigrum, is an alkaloid with a long history of medicinal use. In fact, it exhibits a variety of biochemical and pharmaceutical properties, including chemopreventive activities without significant cytotoxic effects on normal cells, at least at doses < of 250 µg/ml. The aim of this review is to discuss the relevant molecular and cellular mechanisms underlying the chemopreventive action of this natural alkaloid.
AB - Cancer is among the leading causes of death worldwide. Several pharmacological protocols have been developed in order to block tumor progression often showing partial efficacy and severe counterproductive effects. It is now conceived that a healthy lifestyle coupled with the consumption of certain phytochemicals can play a protective role against tumor development and progression. According to this vision, it has been introduced the concept of “chemoprevention”. This term refers to natural agents with the capability to interfere with the tumorigenesis and metastasis, or at least, attenuate the cancer-related symptoms. Piperine (1-Piperoylpiperidine), a main extract of Piper longum and Piper nigrum, is an alkaloid with a long history of medicinal use. In fact, it exhibits a variety of biochemical and pharmaceutical properties, including chemopreventive activities without significant cytotoxic effects on normal cells, at least at doses < of 250 µg/ml. The aim of this review is to discuss the relevant molecular and cellular mechanisms underlying the chemopreventive action of this natural alkaloid.
KW - Cancer therapy
KW - Chemoprevention
KW - Natural compounds
KW - Piperine
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U2 - 10.1007/s11033-019-04927-z
DO - 10.1007/s11033-019-04927-z
M3 - Review article
C2 - 31273611
AN - SCOPUS:85068869361
JO - Molecular Biology Reports
JF - Molecular Biology Reports
SN - 0301-4851
ER -