Piroxicam-β-cyclodextrin has been shown to give pain relief comparable to that with indomethacin and significantly greater than that with naproxen and piroxicam alone in the treatment of primary and migraine headaches. In addition, it would appear to be of use in the prophylaxis of migraine headaches, although further studies are required. The incidence of side effects with piroxicam-β-cyclodextrin was substantially less than that with comparable drugs, particularly with regard to gastrointestinal side effects. In view of its efficacy, tolerability and apparent prophylactic properties, piroxicam-β-cyclodextrin would appear to be a useful analgesic in the treatment of primary or migraine headaches.
ASJC Scopus subject areas
- Pharmacology (medical)