Pituitary function and morphology in Fabry disease

Luigi Maione, Fabio Tortora, Roberta Modica, Valeria Ramundo, Eleonora Riccio, Aurora Daniele, Maria Paola Belfiore, Annamaria Colao, Antonio Pisani, Antongiulio Faggiano

Research output: Contribution to journalArticlepeer-review


Endocrine abnormalities are known to affect patients with Fabry disease (FD). Pituitary gland theoretically represents an ideal target for FD because of high vascularization and low proliferation rate. We explored pituitary morphology and function in a cohort of FD patients through a prospectic, monocentric study at an Academic Tertiary Center. The study population included 28 FD patients and 42 sex and age-matched normal subjects. The protocol included a contrast enhancement pituitary MRI, the assessment of pituitary hormones, anti-pituitary, and anti-hypothalamus antibodies. At pituitary MRI, an empty sella was found in 11 (39 %) FD patients, and in 2 (5 %) controls (p 

Original languageEnglish
Pages (from-to)483-488
Number of pages6
Issue number2
Publication statusPublished - Apr 21 2015


  • Diencephalic MRI
  • Empty sella
  • Fabry disease
  • Pituitary

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism


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