Pituitary function before and after transsphenoidal adenomectomy in patients with Cushing's disease

B. Ambrosi, M. Giovanelli, S. M. Gaini, D. Bochicchio, E. Riva, G. Tomei, M. Zavanone, G. Faglia

Research output: Contribution to journalArticlepeer-review

Abstract

Over the past 4 years 11 patients with Cushing's disease have been operated on by a transsphenoidal microsurgical technique. All patients had small intra-hypophyseal adenomas found at operation. Eight of the 11 patients had a remission of the disease on the basis of clinical evaluation and hormonal studies. The endocrinological results revealed a transient state of hypocorticism in all successfully treated patients. Within 6-8 months after operation recovery of hypothalamic-pituitary-adrenal function and other tropin function took place. These findings, together with the absence of recurrence up to now, further confirm the efficacy of transsphenoidal surgery in the management of patients with Cushing's disease.

Original languageEnglish
Pages (from-to)29-40
Number of pages12
JournalActa Neurochirurgica
Volume65
Issue number1-2
DOIs
Publication statusPublished - Mar 1982

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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