Pituitary gland in Bipolar Disorder and Major Depression: Evidence from structural MRI studies: Special Section on "Translational and Neuroscience Studies in Affective Disorders". Section Editor, Maria Nobile MD, PhD. This Section of JAD focuses on the relevance of translational and neuroscience studies in providing a better understanding of the neural basis of affective disorders. The main aim is to briefly summarise relevant research findings in clinical neuroscience with particular regards to specific innovative topics in mood and anxiety disorders

G Delvecchio, A C Altamura, J C Soares, P Brambilla

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

BACKGROUND: The function of the hypothalamo-pituitary-adrenal axis (HPA) has been widely investigated in mood disorders based on its role in regulating stress response. Particularly, Magnetic Resonance Imaging (MRI) reports have explored pituitary gland (PG) in both bipolar disorder (BD) and major depressive disorder (MDD). In this context, the present review summarizes the results from MRI studies with the final aim of commenting on the presence of common or distinct PG structural alterations between these two disabling illnesses.

METHODS: A bibliographic search on PUBMED of all MRI studies exploring PG volumes in BD and MDD as well as first-degree relatives (RELs) from 2000 up to October 2016 was performed.

RESULTS: Following the screening process of the available literature it can be said that a) PG enlargement has been found in both BD and MDD, therefore potentially representing a common neurobiological marker characterizing mood disorders, and b) PG volumes are moderated by age and sex in both illnesses, although the direction and the extent of this moderation are still not fully clear.

LIMITATIONS: Few MRI studies with heterogeneous results.

CONCLUSIONS: These hypotheses must be taken with caution especially because the heterogeneity of the results of the studies reviewed does not allow for a definite answer about the role of PG in affective disorders. Therefore, larger longitudinal studies investigating PG volumes in BD and MDD patients at the early phases of the illness, by considering females and males separately, are needed to further corroborate these findings.

Original languageEnglish
Pages (from-to)446-450
Number of pages5
JournalJournal of Affective Disorders
Volume218
DOIs
Publication statusPublished - Aug 15 2017

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Pituitary Gland
Neurosciences
Anxiety Disorders
Mood Disorders
Bipolar Disorder
Magnetic Resonance Imaging
Depression
Major Depressive Disorder
Research
Longitudinal Studies

Keywords

  • Adult
  • Bipolar Disorder
  • Depressive Disorder, Major
  • Female
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Mood Disorders
  • Organ Size
  • Pituitary Gland
  • Journal Article
  • Review

Cite this

@article{c174aacff4d9417cac56ffe3cee4faad,
title = "Pituitary gland in Bipolar Disorder and Major Depression: Evidence from structural MRI studies: Special Section on {"}Translational and Neuroscience Studies in Affective Disorders{"}. Section Editor, Maria Nobile MD, PhD. This Section of JAD focuses on the relevance of translational and neuroscience studies in providing a better understanding of the neural basis of affective disorders. The main aim is to briefly summarise relevant research findings in clinical neuroscience with particular regards to specific innovative topics in mood and anxiety disorders",
abstract = "BACKGROUND: The function of the hypothalamo-pituitary-adrenal axis (HPA) has been widely investigated in mood disorders based on its role in regulating stress response. Particularly, Magnetic Resonance Imaging (MRI) reports have explored pituitary gland (PG) in both bipolar disorder (BD) and major depressive disorder (MDD). In this context, the present review summarizes the results from MRI studies with the final aim of commenting on the presence of common or distinct PG structural alterations between these two disabling illnesses.METHODS: A bibliographic search on PUBMED of all MRI studies exploring PG volumes in BD and MDD as well as first-degree relatives (RELs) from 2000 up to October 2016 was performed.RESULTS: Following the screening process of the available literature it can be said that a) PG enlargement has been found in both BD and MDD, therefore potentially representing a common neurobiological marker characterizing mood disorders, and b) PG volumes are moderated by age and sex in both illnesses, although the direction and the extent of this moderation are still not fully clear.LIMITATIONS: Few MRI studies with heterogeneous results.CONCLUSIONS: These hypotheses must be taken with caution especially because the heterogeneity of the results of the studies reviewed does not allow for a definite answer about the role of PG in affective disorders. Therefore, larger longitudinal studies investigating PG volumes in BD and MDD patients at the early phases of the illness, by considering females and males separately, are needed to further corroborate these findings.",
keywords = "Adult, Bipolar Disorder, Depressive Disorder, Major, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Mood Disorders, Organ Size, Pituitary Gland, Journal Article, Review",
author = "G Delvecchio and Altamura, {A C} and Soares, {J C} and P Brambilla",
note = "Copyright {\circledC} 2017 Elsevier B.V. All rights reserved.",
year = "2017",
month = "8",
day = "15",
doi = "10.1016/j.jad.2017.03.066",
language = "English",
volume = "218",
pages = "446--450",
journal = "Journal of Affective Disorders",
issn = "0165-0327",
publisher = "Elsevier",

}

TY - JOUR

T1 - Pituitary gland in Bipolar Disorder and Major Depression

T2 - Evidence from structural MRI studies: Special Section on "Translational and Neuroscience Studies in Affective Disorders". Section Editor, Maria Nobile MD, PhD. This Section of JAD focuses on the relevance of translational and neuroscience studies in providing a better understanding of the neural basis of affective disorders. The main aim is to briefly summarise relevant research findings in clinical neuroscience with particular regards to specific innovative topics in mood and anxiety disorders

AU - Delvecchio, G

AU - Altamura, A C

AU - Soares, J C

AU - Brambilla, P

N1 - Copyright © 2017 Elsevier B.V. All rights reserved.

PY - 2017/8/15

Y1 - 2017/8/15

N2 - BACKGROUND: The function of the hypothalamo-pituitary-adrenal axis (HPA) has been widely investigated in mood disorders based on its role in regulating stress response. Particularly, Magnetic Resonance Imaging (MRI) reports have explored pituitary gland (PG) in both bipolar disorder (BD) and major depressive disorder (MDD). In this context, the present review summarizes the results from MRI studies with the final aim of commenting on the presence of common or distinct PG structural alterations between these two disabling illnesses.METHODS: A bibliographic search on PUBMED of all MRI studies exploring PG volumes in BD and MDD as well as first-degree relatives (RELs) from 2000 up to October 2016 was performed.RESULTS: Following the screening process of the available literature it can be said that a) PG enlargement has been found in both BD and MDD, therefore potentially representing a common neurobiological marker characterizing mood disorders, and b) PG volumes are moderated by age and sex in both illnesses, although the direction and the extent of this moderation are still not fully clear.LIMITATIONS: Few MRI studies with heterogeneous results.CONCLUSIONS: These hypotheses must be taken with caution especially because the heterogeneity of the results of the studies reviewed does not allow for a definite answer about the role of PG in affective disorders. Therefore, larger longitudinal studies investigating PG volumes in BD and MDD patients at the early phases of the illness, by considering females and males separately, are needed to further corroborate these findings.

AB - BACKGROUND: The function of the hypothalamo-pituitary-adrenal axis (HPA) has been widely investigated in mood disorders based on its role in regulating stress response. Particularly, Magnetic Resonance Imaging (MRI) reports have explored pituitary gland (PG) in both bipolar disorder (BD) and major depressive disorder (MDD). In this context, the present review summarizes the results from MRI studies with the final aim of commenting on the presence of common or distinct PG structural alterations between these two disabling illnesses.METHODS: A bibliographic search on PUBMED of all MRI studies exploring PG volumes in BD and MDD as well as first-degree relatives (RELs) from 2000 up to October 2016 was performed.RESULTS: Following the screening process of the available literature it can be said that a) PG enlargement has been found in both BD and MDD, therefore potentially representing a common neurobiological marker characterizing mood disorders, and b) PG volumes are moderated by age and sex in both illnesses, although the direction and the extent of this moderation are still not fully clear.LIMITATIONS: Few MRI studies with heterogeneous results.CONCLUSIONS: These hypotheses must be taken with caution especially because the heterogeneity of the results of the studies reviewed does not allow for a definite answer about the role of PG in affective disorders. Therefore, larger longitudinal studies investigating PG volumes in BD and MDD patients at the early phases of the illness, by considering females and males separately, are needed to further corroborate these findings.

KW - Adult

KW - Bipolar Disorder

KW - Depressive Disorder, Major

KW - Female

KW - Humans

KW - Magnetic Resonance Imaging

KW - Male

KW - Middle Aged

KW - Mood Disorders

KW - Organ Size

KW - Pituitary Gland

KW - Journal Article

KW - Review

U2 - 10.1016/j.jad.2017.03.066

DO - 10.1016/j.jad.2017.03.066

M3 - Review article

C2 - 28412090

VL - 218

SP - 446

EP - 450

JO - Journal of Affective Disorders

JF - Journal of Affective Disorders

SN - 0165-0327

ER -