Pituitary height and neuroradiological alterations in patients with Prader-Labhart-Willi syndrome

L. Iughetti, L. Bosio, A. Corrias, L. Gargantini, L. Ragusa, C. Livieri, B. Predieri, P. Bruzzi, G. Caselli, G. Grugni

Research output: Contribution to journalArticlepeer-review

Abstract

Prader-Willi syndrome (PWS), a genetic disorder due to an alteration in the paternally derived long arm of chromosome 15, is characterized by a complex clinical picture (short stature, obesity, hypogonadism) that seems to be referable to as a central hypothalamic/pituitary dysfunction. To determine whether there is any diminution in the anterior pituitary gland or other neuroradiological alterations, we retrospectively analysed 91 patients with PWS (42 females, 49 males; age range: 0.7-16.8 years) by cerebral magnetic resonance imaging (MRI). Of these 91 patients, MRI analysis showed a reduction in pituitary height in 45 patients (49.4%), a complete absence of the posterior pituitary bright spot in six patients (6.6%) and other neuroradiological alterations in ten patients (11%). Altogether, neuroradiological alterations were present in 61 of the 91 (67%) patients. Our results indicate that neuroradiological alterations are more frequent in PWS patients than has been reported to date.

Original languageEnglish
Pages (from-to)701-702
Number of pages2
JournalEuropean Journal of Pediatrics
Volume167
Issue number6
DOIs
Publication statusPublished - Jun 2008

Keywords

  • Empty sella
  • Pituitary height
  • Prader-Willi syndrome

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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