Pituitary microprolactinoma, bromocriptine, and pregnancy: Follow-up of 74 cases

We performed an endocrinological and radiological study of 74 women with microprolactinoma. All patients underwent continuous treatment with bromocriptine for three to seven years (mean, 5.5 years). During this period tumor size was checked yearly with computerized transaxial tomography and 30 of the patients became pregnant (corrected pregnancy rate was 83.3%). A decrease in microadenoma size occurred in 21.6% of the cases, and apparent disappearance occurred in 27%. Pregnancy did not seem to modify microadenoma growth. In a limited number of cases pregnancy-induced alterations in pituitary blood supply may have caused complete necrosis of the tumoral tissue.