Pituitary-thyroid axis and immune system: A reciprocal neuroendocrine-lmmune interaction

Nicola Fabris, Eugenio Mocchegiani, Mauro Provinciali

Research output: Contribution to journalArticle

80 Citations (Scopus)

Abstract

A good body of experimental and clinical results has supported the existence of numerous reciprocal interactions among the nervous, endocrine and immune systems. Increasing evidence has been accumulated in the last years on the interaction between pituitary-thyroid hormones and the immune system on the basis of either the existence of receptors for thyreotropic and thyroid hormones on lymphocytes or the frequent immune alteration in physiological and pathological fluctuations of thyroid hormones. The data were obtained either in animals with experimentally induced hyper- or hypothyroidism or in humans with various hyperthyroid or hypothyroid situations. Conversely, immune-derived products such as lymphokines and monokines have been shown able to influence the pituitary-thyroid axis modulating either the thyroid hormone levels or the hormone/cytokine production by thyrocytes. The present paper aims at summarizing the data available on the existence of thyroid-immune interactions, and at analyzing the possible integration between pituitary-thyroid hormones and immune factors in favoring the development and maintenance of both thymic and peripheral immune efficiency. The relevance of pituitary-thyroid-immune interactions is discussed for its implication in the ageing process.

Original languageEnglish
Pages (from-to)29-38
Number of pages10
JournalHormone Research in Paediatrics
Volume43
Issue number1-3
DOIs
Publication statusPublished - 1995

Fingerprint

Thyroid Hormones
Immune System
Thyroid Gland
Pituitary Hormones
Hyperthyroidism
Monokines
Thyroid Hormone Receptors
Endocrine System
Lymphokines
Immunologic Factors
Hypothyroidism
Nervous System
Maintenance
Hormones
Lymphocytes
Cytokines

Keywords

  • Agin
  • Immune system
  • Neuroimmunomodulation
  • Pituitary-thyroid axis

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Pediatrics, Perinatology, and Child Health

Cite this

Pituitary-thyroid axis and immune system : A reciprocal neuroendocrine-lmmune interaction. / Fabris, Nicola; Mocchegiani, Eugenio; Provinciali, Mauro.

In: Hormone Research in Paediatrics, Vol. 43, No. 1-3, 1995, p. 29-38.

Research output: Contribution to journalArticle

@article{9785f052a6ad4ce2b9d1b55982ac6078,
title = "Pituitary-thyroid axis and immune system: A reciprocal neuroendocrine-lmmune interaction",
abstract = "A good body of experimental and clinical results has supported the existence of numerous reciprocal interactions among the nervous, endocrine and immune systems. Increasing evidence has been accumulated in the last years on the interaction between pituitary-thyroid hormones and the immune system on the basis of either the existence of receptors for thyreotropic and thyroid hormones on lymphocytes or the frequent immune alteration in physiological and pathological fluctuations of thyroid hormones. The data were obtained either in animals with experimentally induced hyper- or hypothyroidism or in humans with various hyperthyroid or hypothyroid situations. Conversely, immune-derived products such as lymphokines and monokines have been shown able to influence the pituitary-thyroid axis modulating either the thyroid hormone levels or the hormone/cytokine production by thyrocytes. The present paper aims at summarizing the data available on the existence of thyroid-immune interactions, and at analyzing the possible integration between pituitary-thyroid hormones and immune factors in favoring the development and maintenance of both thymic and peripheral immune efficiency. The relevance of pituitary-thyroid-immune interactions is discussed for its implication in the ageing process.",
keywords = "Agin, Immune system, Neuroimmunomodulation, Pituitary-thyroid axis",
author = "Nicola Fabris and Eugenio Mocchegiani and Mauro Provinciali",
year = "1995",
doi = "10.1159/000184234",
language = "English",
volume = "43",
pages = "29--38",
journal = "Hormone Research in Paediatrics",
issn = "1663-2818",
publisher = "S. Karger AG",
number = "1-3",

}

TY - JOUR

T1 - Pituitary-thyroid axis and immune system

T2 - A reciprocal neuroendocrine-lmmune interaction

AU - Fabris, Nicola

AU - Mocchegiani, Eugenio

AU - Provinciali, Mauro

PY - 1995

Y1 - 1995

N2 - A good body of experimental and clinical results has supported the existence of numerous reciprocal interactions among the nervous, endocrine and immune systems. Increasing evidence has been accumulated in the last years on the interaction between pituitary-thyroid hormones and the immune system on the basis of either the existence of receptors for thyreotropic and thyroid hormones on lymphocytes or the frequent immune alteration in physiological and pathological fluctuations of thyroid hormones. The data were obtained either in animals with experimentally induced hyper- or hypothyroidism or in humans with various hyperthyroid or hypothyroid situations. Conversely, immune-derived products such as lymphokines and monokines have been shown able to influence the pituitary-thyroid axis modulating either the thyroid hormone levels or the hormone/cytokine production by thyrocytes. The present paper aims at summarizing the data available on the existence of thyroid-immune interactions, and at analyzing the possible integration between pituitary-thyroid hormones and immune factors in favoring the development and maintenance of both thymic and peripheral immune efficiency. The relevance of pituitary-thyroid-immune interactions is discussed for its implication in the ageing process.

AB - A good body of experimental and clinical results has supported the existence of numerous reciprocal interactions among the nervous, endocrine and immune systems. Increasing evidence has been accumulated in the last years on the interaction between pituitary-thyroid hormones and the immune system on the basis of either the existence of receptors for thyreotropic and thyroid hormones on lymphocytes or the frequent immune alteration in physiological and pathological fluctuations of thyroid hormones. The data were obtained either in animals with experimentally induced hyper- or hypothyroidism or in humans with various hyperthyroid or hypothyroid situations. Conversely, immune-derived products such as lymphokines and monokines have been shown able to influence the pituitary-thyroid axis modulating either the thyroid hormone levels or the hormone/cytokine production by thyrocytes. The present paper aims at summarizing the data available on the existence of thyroid-immune interactions, and at analyzing the possible integration between pituitary-thyroid hormones and immune factors in favoring the development and maintenance of both thymic and peripheral immune efficiency. The relevance of pituitary-thyroid-immune interactions is discussed for its implication in the ageing process.

KW - Agin

KW - Immune system

KW - Neuroimmunomodulation

KW - Pituitary-thyroid axis

UR - http://www.scopus.com/inward/record.url?scp=0028833812&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028833812&partnerID=8YFLogxK

U2 - 10.1159/000184234

DO - 10.1159/000184234

M3 - Article

C2 - 7721259

AN - SCOPUS:0028833812

VL - 43

SP - 29

EP - 38

JO - Hormone Research in Paediatrics

JF - Hormone Research in Paediatrics

SN - 1663-2818

IS - 1-3

ER -