PKU-related dysgammaglobulinaemia: The effect of diet therapy on IgE and allergic sensitization

E. Riva, A. Fiocchi, C. Agostoni, G. Biasucci, M. Sala, G. Banderali, D. Luotti, M. Giovannini

Research output: Contribution to journalArticle

Abstract

The effect of diet on the development of immunoallergic signs and symptoms in children with phenylketonuria (PKU) was evaluated. Immunological indices of 58 children with PKU treated with diets were compared to the immunological indices of 58 healthy (non-PKU) children. In the PKU group, 39 children had been placed on diet therapy within the first month of life; 19 children had been placed on diet therapy after 6 months of age. Total circulating lymphocytes; CD3+, CD4+, CD8+ circulating lymphocytes; and serum IgA, IgM, IgG and total IgE levels were measured for each child. Skin prick tests were performed for common inhalant and food allergens. Every 3 months over the 2-year period of this study, the signs and symptoms of eczema, allergic rhinitis and asthma were recorded. The PKU group had lower IgG levels (p=0.004) and higher total IgE levels (p=0.0001) than the control group. Significantly lower IgE levels were found in children started on diet therapy within the first month of life compared with those started on diet therapy after 6 months of age (p=0.0001). Allergic sensitization was significantly more frequent in the PKU group (24/58 vs 13/58, z=2.00, p

Original languageEnglish
Pages (from-to)710-717
Number of pages8
JournalJournal of Inherited Metabolic Disease
Volume17
Issue number6
DOIs
Publication statusPublished - Nov 1994

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics
  • Endocrinology

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