Pla a 2 and Pla a 3 reactivities identify plane tree-allergic patients with respiratory symptoms or food allergy

E. Scala, L. Cecchi, D. Abeni, E. C. Guerra, L. Pirrotta, Maria Locanto, Mauro Giani, R. Asero

Research output: Contribution to journalArticle


Nine hundred and thirty-nine rPla a 1, nPla a 2, and rPla a 3 ImmunoCAP ISAC reactors were studied. nPla a 2pos MUXF3pos but Pla a 1/2neg subjects were excluded from the study because they were cross-reactive carbohydrate determinant reactors. Among the 764 remaining participants, 71.9% were Pla a 3pos, 54.1% Pla a 2pos, and 10.9% Pla a 1pos. Among Pla a 3 reactors, 89.6% were Pru p 3pos and 86.8% Jug 3pos, but the strongest IgE recognition relationship was observed between Pla a 3 and Jug r 3. Distinctive clinical subsets could be documented among plane tree-allergic patients. Pla a 3 reactors had both local and systemic food-induced reactions, but lower past respiratory symptoms occurrence. Pla a 2 reactivity was associated with respiratory symptoms but inversely related to systemic reactions to food. Cosensitization to Pla a 2 and Pla a 3 was associated with a lower past incidence of severe food-induced reactions.

Original languageEnglish
Pages (from-to)671-674
Number of pages4
JournalAllergy: European Journal of Allergy and Clinical Immunology
Issue number4
Publication statusPublished - Apr 1 2017



  • Jug r 3
  • nonspecific lipid transfer protein
  • Pla a 2
  • Pla a 3
  • plane tree

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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