Placental Growth Factor and Cardiac Inflammation

Research output: Contribution to journalArticlepeer-review


Placental growth factor (PlGF) belongs to the vascular endothelial growth factor family and is one of the most interesting candidates as an "angiogenic cytokine," capable of not only controlling angiogenic functions but also finely regulating the inflammatory response. Because inflammatory response and, in particular, recruitment of monocyte/macrophage lineage cells are processes strictly connected to the cardiovascular system in health and disease, PlGF appears to be an intriguing player in the interplay of these phenomena. This review discusses recent findings unraveling novel functions of PlGF in ruling the inflammatory response during cardiac remodeling to pressure overload and the ensuing therapeutic implications and future directions for research.

Original languageEnglish
Pages (from-to)209-212
Number of pages4
JournalTrends in Cardiovascular Medicine
Issue number8
Publication statusPublished - Nov 2012

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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