Placental transfer and retention of 201Tl-thallium in the rat

J. Edel Rade, E. Marafante, E. Sabbioni, C. Gregotti, A. Di Nucci, L. Manzo

Research output: Contribution to journalArticle

Abstract

Placental transfer of thallium was evidenced in rats treated with a single intraperitoneal dose of 2 μg 201Tl-labelled thallium/rat on the 13th day of pregnancy. Both maternai and fetal organs showed remarkable thallium retention, approx. 10% of the dose being unexcreted 8 days after injection. The highest thallium accumulation was found in maternal muscle and brain tissues. Fetal brain exhibited higher thallium uptake and faster decay rate of thallium levels than maternal brain. It is suggested that the reduced activity of the mechanisms regulating ion movements and composition of nervous tissue and the immaturity of the blood-brain barrier play a role in the peculiar pattern of thallium kinetics in the developing rat brain.

Original languageEnglish
Pages (from-to)275-280
Number of pages6
JournalToxicology Letters
Volume11
Issue number3-4
DOIs
Publication statusPublished - 1982

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Thallium
Rats
Brain
Mothers
Tissue
Nerve Tissue
Blood-Brain Barrier
Muscle
Ions
Pregnancy
Muscles
Injections
Kinetics
Chemical analysis

ASJC Scopus subject areas

  • Toxicology

Cite this

Rade, J. E., Marafante, E., Sabbioni, E., Gregotti, C., Di Nucci, A., & Manzo, L. (1982). Placental transfer and retention of 201Tl-thallium in the rat. Toxicology Letters, 11(3-4), 275-280. https://doi.org/10.1016/0378-4274(82)90161-8

Placental transfer and retention of 201Tl-thallium in the rat. / Rade, J. Edel; Marafante, E.; Sabbioni, E.; Gregotti, C.; Di Nucci, A.; Manzo, L.

In: Toxicology Letters, Vol. 11, No. 3-4, 1982, p. 275-280.

Research output: Contribution to journalArticle

Rade, JE, Marafante, E, Sabbioni, E, Gregotti, C, Di Nucci, A & Manzo, L 1982, 'Placental transfer and retention of 201Tl-thallium in the rat', Toxicology Letters, vol. 11, no. 3-4, pp. 275-280. https://doi.org/10.1016/0378-4274(82)90161-8
Rade JE, Marafante E, Sabbioni E, Gregotti C, Di Nucci A, Manzo L. Placental transfer and retention of 201Tl-thallium in the rat. Toxicology Letters. 1982;11(3-4):275-280. https://doi.org/10.1016/0378-4274(82)90161-8
Rade, J. Edel ; Marafante, E. ; Sabbioni, E. ; Gregotti, C. ; Di Nucci, A. ; Manzo, L. / Placental transfer and retention of 201Tl-thallium in the rat. In: Toxicology Letters. 1982 ; Vol. 11, No. 3-4. pp. 275-280.
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