Placental transfer of diazepam and its disposition in the newborn

M. Mandelli, P. L. Morselli, S. Nordio, G. Pardi, N. Principi, F. Sereni, G. Tognoni

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Abstract

Diazepam (DZ) placental transfer in pregnant women at term, following single or repeated drug administration by various routes, was evaluated. DZ and its metabolite N-demethyldiazepam (NDZ) were constantly present in umbilical cord plasma at concentrations comparable to the mother's shortly after drug administration. N-methyloxazepam (MOX) was detected in cord plasma only in a limited number of cases following chronic DZ treatment. Postmortem analysis of fetal tissue concentrations showed accumulation of ND Z in heart and lungs. Differences in NDZ concentrations between venous cord (VC) and arterial cord (AC) plasma suggest metabolic degradation of DZ in the fetus. The DZ apparent plasma half-life in the newborn was found to be longer (31 ± 2 hr) than previously observed in infants and children. The low drug clearance appears to be linked to reduced urinary excretion of hydroxylated metabolites, suggesting limited capability to dispose of DZ in the newborn.

Original languageEnglish
Pages (from-to)564-572
Number of pages9
JournalClinical Pharmacology and Therapeutics
Volume17
Issue number5
Publication statusPublished - May 1975

Fingerprint

Diazepam
Newborn Infant
Nordazepam
Fetus
Drug Administration Routes
Temazepam
Umbilical Cord
Pharmaceutical Preparations
Half-Life
Pregnant Women
Mothers
Lung

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

Cite this

Mandelli, M., Morselli, P. L., Nordio, S., Pardi, G., Principi, N., Sereni, F., & Tognoni, G. (1975). Placental transfer of diazepam and its disposition in the newborn. Clinical Pharmacology and Therapeutics, 17(5), 564-572.

Placental transfer of diazepam and its disposition in the newborn. / Mandelli, M.; Morselli, P. L.; Nordio, S.; Pardi, G.; Principi, N.; Sereni, F.; Tognoni, G.

In: Clinical Pharmacology and Therapeutics, Vol. 17, No. 5, 05.1975, p. 564-572.

Research output: Contribution to journalArticle

Mandelli, M, Morselli, PL, Nordio, S, Pardi, G, Principi, N, Sereni, F & Tognoni, G 1975, 'Placental transfer of diazepam and its disposition in the newborn', Clinical Pharmacology and Therapeutics, vol. 17, no. 5, pp. 564-572.
Mandelli M, Morselli PL, Nordio S, Pardi G, Principi N, Sereni F et al. Placental transfer of diazepam and its disposition in the newborn. Clinical Pharmacology and Therapeutics. 1975 May;17(5):564-572.
Mandelli, M. ; Morselli, P. L. ; Nordio, S. ; Pardi, G. ; Principi, N. ; Sereni, F. ; Tognoni, G. / Placental transfer of diazepam and its disposition in the newborn. In: Clinical Pharmacology and Therapeutics. 1975 ; Vol. 17, No. 5. pp. 564-572.
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