Placental transmogrification of the lung: Clinicopathologic, immunohistochemical and molecular study of two cases, with particular emphasis on the interstitial clear cells

Alberto Cavazza, Sylvie Lantuejoul, Giuliana Sartori, Nazzarena Bigiani, Antonio Maiorana, Gianandrea Pasquinelli, Massimiliano Paci, Giulio Rossi

Research output: Contribution to journalArticle

Abstract

Two cases of placental transmogrification of the lung are reported. The lesions presented in the left lung, in one case as a giant bulla of the upper lobe and in the other as a cystic nodule of the lower lobe. A segmentectomy was performed in both cases, and the patients were alive and well 5 years and 2 months after surgery, respectively. In our opinion, pulmonary placental transmogrificafion is not a variant of emphysema, as generally considered, but rather probably represents a benign proliferation of immature interstitial clear cells with secondary cystic change. This report presents a histological, immunohistochemical, ultrastructural and molecular study of these peculiar cells, together with a review of the literature.

Original languageEnglish
Pages (from-to)517-521
Number of pages5
JournalHuman Pathology
Volume35
Issue number4
DOIs
Publication statusPublished - Apr 2004

Keywords

  • Emphysema
  • Immunohistochemistry
  • Lung
  • Microsatellite instability
  • Placental transmogrification

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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