TY - JOUR
T1 - Placental transmogrification of the lung
T2 - Clinicopathologic, immunohistochemical and molecular study of two cases, with particular emphasis on the interstitial clear cells
AU - Cavazza, Alberto
AU - Lantuejoul, Sylvie
AU - Sartori, Giuliana
AU - Bigiani, Nazzarena
AU - Maiorana, Antonio
AU - Pasquinelli, Gianandrea
AU - Paci, Massimiliano
AU - Rossi, Giulio
PY - 2004/4
Y1 - 2004/4
N2 - Two cases of placental transmogrification of the lung are reported. The lesions presented in the left lung, in one case as a giant bulla of the upper lobe and in the other as a cystic nodule of the lower lobe. A segmentectomy was performed in both cases, and the patients were alive and well 5 years and 2 months after surgery, respectively. In our opinion, pulmonary placental transmogrificafion is not a variant of emphysema, as generally considered, but rather probably represents a benign proliferation of immature interstitial clear cells with secondary cystic change. This report presents a histological, immunohistochemical, ultrastructural and molecular study of these peculiar cells, together with a review of the literature.
AB - Two cases of placental transmogrification of the lung are reported. The lesions presented in the left lung, in one case as a giant bulla of the upper lobe and in the other as a cystic nodule of the lower lobe. A segmentectomy was performed in both cases, and the patients were alive and well 5 years and 2 months after surgery, respectively. In our opinion, pulmonary placental transmogrificafion is not a variant of emphysema, as generally considered, but rather probably represents a benign proliferation of immature interstitial clear cells with secondary cystic change. This report presents a histological, immunohistochemical, ultrastructural and molecular study of these peculiar cells, together with a review of the literature.
KW - Emphysema
KW - Immunohistochemistry
KW - Lung
KW - Microsatellite instability
KW - Placental transmogrification
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U2 - 10.1016/j.humpath.2003.10.023
DO - 10.1016/j.humpath.2003.10.023
M3 - Article
C2 - 15116336
AN - SCOPUS:1942517755
VL - 35
SP - 517
EP - 521
JO - Human Pathology
JF - Human Pathology
SN - 0046-8177
IS - 4
ER -