Plan robustness in field junction region from arcs with different patient orientation in total marrow irradiation with VMAT

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The cranial-caudal (CC) maximum LINAC couch shift is usually around 130-150 cm; therefore total marrow (and lymph-nodes) irradiation (TMI-TMLI) requires two different plans, one with patient head-first-supine ("body plan" - skull-thighs) and a second feet-first-supine ("legs plan" - feet-femurs head). A challenging planning is required to manage the region in which the radiation come from the two plans (that cannot be automatically optimized together). We studied a robust way to produce a plan sum in this field junction region without creating under/over dosage on PTV and hotspots out. Material and methods: Twenty-one patients candidates to bone marrow transplantation were treated with TMI-TMLI on TrueBeam using RapidArc technique. All body bones were defined as PTV and, for TMLI, lymph-nodes and spleen were included, too. The two plans according to ALARA principle were optimized. In particular, in the overlapping region (PTVJ), two specular sigmoid dosimetric shapes were adopted for obtaining homogeneous integral dose. Furthermore, 144 plans from four patients were calculated to evaluate plan robustness. Results: In all patients, 95% of the prescription dose covered >99% of PTVJ. Regarding the robustness study, differences

Original languageEnglish
Pages (from-to)677-682
Number of pages6
JournalPhysica Medica
Volume31
Issue number7
DOIs
Publication statusPublished - Nov 1 2015

Keywords

  • Field junction
  • Radiotherapy
  • Total marrow irradiation
  • Volumetric modulated arc therapy (VMAT)

ASJC Scopus subject areas

  • Biophysics
  • Radiology Nuclear Medicine and imaging
  • Physics and Astronomy(all)

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