Abstract
| Original language | English |
|---|---|
| Pages (from-to) | E271-E277 |
| Number of pages | 7 |
| Journal | Catheterization and Cardiovascular Interventions |
| Volume | 92 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2018 |
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Planned angiographic control versus clinical follow-up for patients with unprotected left main stem stenosis treated with second generation drug-eluting stents: A propensity score with matching analysis from the FAILS (failure in left main with second generation stents-Cardiogroup III Study). / D'Ascenzo, F; Iannaccone, M; Pavani, Marco; Kawamoto, H; Escaned, J; Varbella, F; Boccuzzi, Giacomo; Hiddick-Smith, D; Colombo, A; Gaita, F.
In: Catheterization and Cardiovascular Interventions, Vol. 92, No. 4, 2018, p. E271-E277.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Planned angiographic control versus clinical follow-up for patients with unprotected left main stem stenosis treated with second generation drug-eluting stents: A propensity score with matching analysis from the FAILS (failure in left main with second generation stents-Cardiogroup III Study)
AU - D'Ascenzo, F
AU - Iannaccone, M
AU - Pavani, Marco
AU - Kawamoto, H
AU - Escaned, J
AU - Varbella, F
AU - Boccuzzi, Giacomo
AU - Hiddick-Smith, D
AU - Colombo, A
AU - Gaita, F
PY - 2018
Y1 - 2018
N2 - Background: The value of angiographic follow-up in unprotected left main (ULM) stenting remains undefined. Methods: The FAILS-2 registry included consecutive patients presenting with a critical lesion of an ULM treated with second generation drug eluting stents in 6 centers from June 2007 to January 2015. Patients were stratified into two groups: those discharged with planned angiographic follow-up and those with clinical follow-up. MACE (Major Adverse Clinical Events, a composite end point of death, myocardial infarction, TLR, and ST) was the primary end point, while each component was a secondary endpoint Sensitivity analysis was performed for patients treated with a provisional or a two-stent strategy. A propensity score analysis was used to compare the outcomes in the two groups. Results: After multivariate adjustment, 220 patients per group were selected. Planned angiographic follow up was performed after a median of 7 (6-10) months. After 16 (14-21) months, rates of MACE were similar between the two groups (24 vs. 21%, P=0.29) with lower rates of all cause and cardiovascular death in the angiographic control group (6 vs. 14%, P=0.01 and 3 vs. 6%, P=0.04) but with higher rates of TLR (15 vs. 5%, P <0.001). The same trend was seen irrespective of the stent strategy. Conclusion: planned angiographic control results in more TLR but may reduce mortality. These findings need to be confirmed by adequately powered randomized controlled trial. © 2017 Wiley Periodicals, Inc.
AB - Background: The value of angiographic follow-up in unprotected left main (ULM) stenting remains undefined. Methods: The FAILS-2 registry included consecutive patients presenting with a critical lesion of an ULM treated with second generation drug eluting stents in 6 centers from June 2007 to January 2015. Patients were stratified into two groups: those discharged with planned angiographic follow-up and those with clinical follow-up. MACE (Major Adverse Clinical Events, a composite end point of death, myocardial infarction, TLR, and ST) was the primary end point, while each component was a secondary endpoint Sensitivity analysis was performed for patients treated with a provisional or a two-stent strategy. A propensity score analysis was used to compare the outcomes in the two groups. Results: After multivariate adjustment, 220 patients per group were selected. Planned angiographic follow up was performed after a median of 7 (6-10) months. After 16 (14-21) months, rates of MACE were similar between the two groups (24 vs. 21%, P=0.29) with lower rates of all cause and cardiovascular death in the angiographic control group (6 vs. 14%, P=0.01 and 3 vs. 6%, P=0.04) but with higher rates of TLR (15 vs. 5%, P <0.001). The same trend was seen irrespective of the stent strategy. Conclusion: planned angiographic control results in more TLR but may reduce mortality. These findings need to be confirmed by adequately powered randomized controlled trial. © 2017 Wiley Periodicals, Inc.
U2 - 10.1002/ccd.27408
DO - 10.1002/ccd.27408
M3 - Article
VL - 92
SP - E271-E277
JO - Catheterization and Cardiovascular Interventions
JF - Catheterization and Cardiovascular Interventions
SN - 1522-1946
IS - 4
ER -