Planned neck dissection after chemoradiotherapy in advanced oropharyngeal squamous cell cancer: The role of US, MRI and FDG-PET/TC scans to assess residual neck disease

Raul Pellini, Valentina Manciocco, Mario Turri-Zanoni, Antonello Vidiri, Giuseppe Sanguineti, Laura Marucci, Rosa Sciuto, Renato Covello, Isabella Sperduti, Ramy Kayal, Vincenzo Anelli, Barbara Pichi, Giuseppe Mercante, Giuseppe Spriano

Research output: Contribution to journalArticle

Abstract

Objective To investigate the ability of neck ultrasounds (US), magnetic resonance imaging (MRI) and positron emission tomography (FDG-PET/TC) in detecting residual nodal disease after chemoradiotherapy in patients with advanced oropharyngeal squamous cell carcinoma (OPSCC).

Methods From 2006 to 2009, 36 consecutive patients affected by OPSCC with bulky nodal disease (>3 cm), treated with primary concurrent chemoradiotherapy, were enrolled prospectively. Nodal response to treatment was assessed by using US, MRI and FDG-PET/CT. Planned neck dissection (ND) was performed in all the patients, and the histopathological node status was compared to the imaging findings in order to establish sensitivity, specificity, accuracy and predictive values of each technique.

Results Metastatic disease was assessed in 18/37 (48.6%) hemi-necks, always localized in levels II-IV. US showed greater sensitivity (77.8%) and, combined with FDG-PET/TC, produced the highest negative predictive value (93.3%). US, MRI and FDG-PET/TC scans showed the highest specificity (100%), accuracy (93.8%) and positive predictive values (100%).

Conclusions In the presence of advanced OPSCC with bulky nodal disease, US combined with FDG-PET/TC could be a reliable and cost-effective strategy to identify patients with complete nodal response to chemoradiotherapy that might not require post-treatment ND but only observation. When residual disease in the neck was detected, selective ND was recommended.

Original languageEnglish
Pages (from-to)1834-1839
Number of pages6
JournalJournal of Cranio-Maxillofacial Surgery
Volume42
Issue number8
DOIs
Publication statusPublished - Dec 1 2014

Keywords

  • Chemoradiotherapy
  • FDG-PET-CT
  • Neck ultrasound
  • Oropharyngeal cancer
  • Planned neck dissection

ASJC Scopus subject areas

  • Oral Surgery
  • Otorhinolaryngology
  • Surgery

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