TY - JOUR
T1 - Plant-derived natural compounds in genetic vaccination and therapy for HPV-associated cancers
AU - Franconi, Rosella
AU - Massa, Silvia
AU - Paolini, Francesca
AU - Vici, Patrizia
AU - Venuti, Aldo
N1 - Funding Information:
This research was partially funded by a Research Project ?Regione Lazio-Lazio-Innova, " funded under the L.R. 13/2008. Prot.# 85-2017-15170.
Publisher Copyright:
© 2020 by the authors.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/11
Y1 - 2020/11
N2 - Antigen-specific immunotherapy and, in particular, DNA vaccination provides an established approach for tackling human papillomavirus (HPV) cancers at different stages. DNA vaccines are stable and have a cost-effective production. Their intrinsic low immunogenicity has been improved by several strategies with some success, including fusion of HPV antigens with plant gene sequences. Another approach for the control of HPV cancers is the use of natural immunomodulatory agents like those derived from plants, that are able to interfere in carcinogenesis by modulating many different cellular pathways and, in some instances, to reduce chemo- and radiotherapy resistance of tumors. Indeed, plant-derived compounds represent, in many cases, an abundantly available, cost-effective source of molecules that can be either harvested directly in nature or obtained from plant cell cultures. In this review, an overview of the most relevant data reported in literature on the use of plant natural compounds and genetic vaccines that include plant-derived sequences against HPV tumors is provided. The purpose is also to highlight the still under-explored potential of multimodal treatments implying DNA vaccination along with plant-derived agents.
AB - Antigen-specific immunotherapy and, in particular, DNA vaccination provides an established approach for tackling human papillomavirus (HPV) cancers at different stages. DNA vaccines are stable and have a cost-effective production. Their intrinsic low immunogenicity has been improved by several strategies with some success, including fusion of HPV antigens with plant gene sequences. Another approach for the control of HPV cancers is the use of natural immunomodulatory agents like those derived from plants, that are able to interfere in carcinogenesis by modulating many different cellular pathways and, in some instances, to reduce chemo- and radiotherapy resistance of tumors. Indeed, plant-derived compounds represent, in many cases, an abundantly available, cost-effective source of molecules that can be either harvested directly in nature or obtained from plant cell cultures. In this review, an overview of the most relevant data reported in literature on the use of plant natural compounds and genetic vaccines that include plant-derived sequences against HPV tumors is provided. The purpose is also to highlight the still under-explored potential of multimodal treatments implying DNA vaccination along with plant-derived agents.
KW - Chimeric vaccine
KW - Combined DNA vaccine/plant molecule therapy
KW - DNA vaccination
KW - HPV-related tumors
KW - Immunomodulation
KW - Immunotherapy
KW - Multimodal treatments
KW - Plant molecules
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U2 - 10.3390/cancers12113101
DO - 10.3390/cancers12113101
M3 - Article
AN - SCOPUS:85094217320
VL - 12
SP - 1
EP - 38
JO - Cancers
JF - Cancers
SN - 2072-6694
IS - 11
M1 - 3101
ER -