Plant polyphenols effectively protect HaCaT cells from ultraviolet C-triggered necrosis and suppress inflammatory chemokine expression

Saveria Pastore, Alla Potapovich, Vladimir Kostyuk, Valentina Mariani, Daniela Lulli, Chiara De Luca, Liudmila Korkina

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Oxidative stress is a common response of epidermal cells to a variety of noxious stimuli such as ultraviolet (UV) radiation from solar light and proinflammatory cytokines from skin-infiltrating leukocytes. Here, we report that two types of plant-derived antioxidants, the phenylpropanoid glycoside verbascoside as well as the flavonoids rutin and quercetin possess protective effects against UVC-induced cell damage and proinflammatory activation. The molecules under investigation were effective against the loss of cell integrity associated with necrosis in doses consistent with their antioxidant activity, whereas they did not significantly oppose UVC-induced proliferation arrest and apoptosis. By contrast, only verbascoside effectively inhibited cytokine-induced release of proinflammatory mediators in a dose-dependent fashion. Verbascoside and its homologue teupolioside dramatically impaired NF-κB and AP-1 DNA binding activity. These results suggest that plant polyphenols with antioxidant properties have distinct mechanisms in the suppression of oxidative stress induced in keratinocytes by different stimuli. Verbascoside and teupolioside are hence of potential interest in the protection of the skin from both environmental and inflammatory insults.

Original languageEnglish
Title of host publicationAnnals of the New York Academy of Sciences
Pages305-313
Number of pages9
Volume1171
DOIs
Publication statusPublished - Aug 2009

Publication series

NameAnnals of the New York Academy of Sciences
Volume1171
ISSN (Print)00778923
ISSN (Electronic)17496632

Keywords

  • AP-1
  • Apoptosis
  • Chemokine
  • Necrosis
  • NF-κB
  • Quercetin
  • Rutin
  • Teupolioside
  • UVC
  • Verbascoside

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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