Plant polyphenols inhibit VacA, a toxin secreted by the gastric pathogen Helicobacter pylori

Francesco Tombola, Silvia Campello, Laura De Luca, Paolo Ruggiero, Giuseppe Del Giudice, Emanuele Papini, Mario Zoratti

Research output: Contribution to journalArticlepeer-review

Abstract

VacA is a major virulence factor of the widespread stomach-dwelling bacterium Helicobacter pylori. It causes cell vacuolation and tissue damage by forming anion-selective, urea-permeable channels in plasma and endosomal membranes. We report that several flavone derivatives and other polyphenols present in vegetables and plants inhibit ion and urea conduction and cell vacuolation by VacA. Red wine and green tea, which contain many of the compounds in question, also potently inhibit the toxin. These observations suggest that polyphenols or polyphenol derivatives may be useful in the prevention or cure of H. pylori-associated gastric diseases.

Original languageEnglish
Pages (from-to)184-189
Number of pages6
JournalFEBS Letters
Volume543
Issue number1-3
DOIs
Publication statusPublished - May 22 2003

Keywords

  • Flavone
  • Gastritis
  • Green tea
  • Helicobacter pylori
  • Polyphenol
  • VacA

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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