Plasma β-endorphin response to exercise in patients with congestive heart failure

Gian Piero Perna, Sergio Modoni, Guido Valle, Mario Stanislao, Francesco Loperfido

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To determine whether the net release of β-endorphin during exercise, similar to that of norepinephrine, is related to functional disability in patients with congestive heart failure. Background: Plasma β- endorphin and norepinephrine levels are elevated at rest in patients with heart failure, reflecting a functional disability. The net release of β- endorphin during exercise in patients with heart failure is unknown. Methods: We measured plasma β-endorphin and norepinephrine levels (respectively: radioimmune and radioenzymatic assay) at rest and during graded exercise testing in 28 patients with congestive heart failure (Weber's class A, 10; B, 9; and C, 9) and in 9 normal subjects. Results: At rest, plasma β-endorphin levels were higher in patients in classes B and C than in normal subjects (p

Original languageEnglish
Pages (from-to)19-22
Number of pages4
JournalChest
Volume111
Issue number1
Publication statusPublished - 1997

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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