Plasma ACTH-response to the corticotropin releasing factor in patients with Cushing's disease. Comparison with the lysine-vasopressin test

Anna Catania, Luigi Cantalamessa, Alessandra Orsatti, Giuseppina Mosca, Francesca Minonzio, Paola Motta, Eugenio Reschini, Carlo Zanussi

Research output: Contribution to journalArticle

Abstract

In three female patients with Cushing's disease, 100 μg of synthetic ovine corticotropin releasing factor (CRF) were administered before surgery and 1 week after transsphenoidal microadenomectomy. In these patients a test with lysine-vasopressin (LVP), 10 U intramuscularly, was also performed before and after pituitary surgery. Before surgery, both stimuli induced a clear increase in plasma ACTH and cortisol in all patients; the response of ACTH to CRF was of greater magnitude. Postoperatively, the responses were virtually absent in two patients, but were still present in the third one in whom the removal of adenoma had been partially unsuccessful. The CRF test was also performed in a female patient with Cushing's syndrome due to adrenal adenoma; in this patient no responses of plasma ACTH and cortisol to CRF were recorded. This paper demonstrates that pituitary microadenomas causing Cushing's disease may retain the ability to respond to CRF; this stimulus may be useful in the differential diagnosis between ACTH-dependent and independent Cushing's syndrome; the lack of response after microadenomectomy indicates successful removal of the tumor. CRF is more potent than LVP in releasing ACTH at the doses employed.

Original languageEnglish
Pages (from-to)478-481
Number of pages4
JournalMetabolism
Volume33
Issue number5
DOIs
Publication statusPublished - 1984

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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    Catania, A., Cantalamessa, L., Orsatti, A., Mosca, G., Minonzio, F., Motta, P., Reschini, E., & Zanussi, C. (1984). Plasma ACTH-response to the corticotropin releasing factor in patients with Cushing's disease. Comparison with the lysine-vasopressin test. Metabolism, 33(5), 478-481. https://doi.org/10.1016/0026-0495(84)90151-3