Abstract
Background and aims: Adiponectin (ADPN) as an adipose tissue hormone contributes to regulation of energy metabolism and body composition and is associated with cardiovascular risk profile parameters. Cardiac cachexia may develop as a result of severe catabolic derangement in chronic heart failure (CHF). We aimed to determinate an abnormal ADPN regulation as a link between catabolic signalling, symptomatic deterioration and poor prognosis. Methods and results: We measured plasma ADPN in 111 CHF patients (age 65±11, 90% male, left ventricular ejection fraction (LVEF) 36±11%, peak oxygen consumption (peakVO2) 18.1±5.7l/kg*min, body mass index (BMI) 27±4 kg/m2, all mean±standard deviation) and 36 healthy controls of similar age and BMI. Body composition was assessed by dual energy X-ray absorptiometry, insulin sensitivity was evaluated by homoeostasis model assessment, exercise capacity by spiroergometry. Plasma ADPN did not differ between CHF vs. controls (13.5±11.0 vs. 10.5±5.3 mg/l, p>0.4), but increased stepwise with NYHA functional class (I/II/III: 5.7±1.4/10.7±8.3/19.2±14.0 mg/l, ANOVA p2 at anaerobic threshold (r=-0.34, p
Original language | English |
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Pages (from-to) | 50-56 |
Number of pages | 7 |
Journal | Nutrition, Metabolism and Cardiovascular Diseases |
Volume | 24 |
Issue number | 1 |
DOIs | |
Publication status | Published - 2014 |
Keywords
- Adiponectin
- ADPN
- AT
- BMI
- Cachexia
- CCHF
- CHF
- Chronic heart failure
- DEXA
- HOMA
- LVEF
- Metabolism
- NcCHF
- NYHA
- ProANP
- RER
- VE
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Nutrition and Dietetics
- Endocrinology, Diabetes and Metabolism
- Cardiology and Cardiovascular Medicine