Plasma adiponectin levels and endometrial cancer risk in pre- and postmenopausal women

Anne E. Cust, Rudolf Kaaks, Christine Friedenreich, Fabrice Bonnet, Martine Laville, Annekatrin Lukanova, Sabina Rinaldi, Laure Dossus, Nadia Slimani, Eva Lundin, Anne Tjønneland, Anja Olsen, Kim Overvad, Françoise Clavel-Chapelon, Sylvie Mesrine, Virginie Joulin, Jakob Linseisen, Sabine Rohrmann, Tobias Pischon, Heiner BoeingDimitrios Trichopoulos, Antonia Trichopoulou, Vassiliki Benetou, Domenico Palli, Franco Berrino, Rosario Tumino, Carlotta Sacerdote, Amalia Mattiello, J. Ramón Quirós, Michelle A. Mendez, María José Sánchez, Nerea Larrañaga, M. J. Tormo, Eva Ardanaz, H. Bas Bueno-de-Mesquita, Petra H M Peeters, Carla H. Van Gils, Kay Tee Khaw, Sheila Bingham, Naomi Allen, Tim Key, Mazda Jenab, Elio Riboli

Research output: Contribution to journalArticlepeer-review


Background: Adiponectin, an adipocytokine secreted by adipose tissue, is decreased in obesity, insulin resistance, type 2 diabetes, and polycystic ovary syndrome, all of which are well-established risk factors for endometrial cancer. Methods: We conducted a case-control study nested within the European Prospective Investigation into Cancer and Nutrition to examine the relation between prediagnostic plasma adiponectin levels and endometrial cancer risk. Among pre- and postmenopausal women who were not currently using exogenous hormones, 284 women developed incident endometrial cancer during an average of 5.1 yr of follow-up. Using risk set sampling, 548 control subjects were selected, matched on center, age, menopausal status, phase of menstrual cycle, time of blood draw, and fasting status. Conditional logistic regression models were used to estimate relative risks and 95% confidence intervals. Results: Adiponectin levels were inversely associated with endometrial cancer risk [body mass index-adjusted relative risk for the top vs. bottom quartile = 0.56 (95% confidence interval 0.36-0.86), Ptrend = 0.006]. There was evidence of a stronger inverse association among obese women than among nonobese women (Pheterogeneity = 0.03). The inverse association also appeared stronger for women who were postmenopausal or perimenopausal than premenopausal at baseline, but this was not statistically significantly heterogeneous (P heterogeneity = 0.51). The association remained statistically significant after separate adjustment for other obesity-related physiological risk factors such as C-peptide, IGF binding protein-1, IGF binding protein-2, SHBG, estrone, or free testosterone but only marginally statistically significant after simultaneous adjustment for these factors. Conclusions: High circulating adiponectin levels are associated with reduced endometrial cancer risk, largely independent of other obesity-related risk factors.

Original languageEnglish
Pages (from-to)255-263
Number of pages9
JournalJournal of Clinical Endocrinology and Metabolism
Issue number1
Publication statusPublished - Jan 2007

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism


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