Plasma adrenaline and noradrenaline concentrations in diabetic patients with and without autonomic neuropathy at rest and during sympathetic stimulation

F. Caviezel, G. B. Picotti, A. Margonato, G. Slaviero, M. D. Galva, P. Camagna, G. P. Bondiolotti, M. O. Carruba, G. Pozza

Research output: Contribution to journalArticlepeer-review

Abstract

Plasma concentrations of adrenaline and noradrenaline were measured radio-enzymatically in nine patients with diabetic autonomic neuropathy, seven diabetic patients without autonomic neuropathy and nine normal subjects, in the recumbent position and after standing. Furthermore, in six patients with autonomic neuropathy and in the normal subjects, plasma noradrenaline and adrenaline concentrations were determined during and after cyclo-ergometer exercise. No differences in plasma adrenaline concentrations were found at any time in the study. Basal plasma noradrenaline levels were significantly lower in diabetic patients with autonomic neuropathy than in the non-neuropathic diabetics or healthy control subjects. After standing, plasma noradrenaline rose to significantly higher levels in both control and diabetic subjects without neuropathy than in the patients with autonomic neuropathy. During exercise (up to 100 W load), plasma noradrenaline rose to similar levels in healthy controls and in patients with diabetic neuropathy. These data indicate that in diabetic autonomic neuropathy there is reduced peripheral neurosympathetic tone at rest but a normal response to moderate exercise. Blunted neurosympathetic responses to standing seem to be a consistent feature of diabetic autonomic neuropathy, particularly in those patients with severe postural hypotension.

Original languageEnglish
Pages (from-to)19-23
Number of pages5
JournalDiabetologia
Volume23
Issue number1
DOIs
Publication statusPublished - Jul 1982

Keywords

  • adrenaline, noradrenaline
  • autonomic neuropathy
  • diabetes mellitus
  • muscular exercise
  • orthostatic hypotension
  • Plasma catecholamines
  • postural stimulation
  • sympathetic nervous activity

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

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