Plasma and brain kinetics of large neutral amino acids and of striatum monoamines in rats given aspartame

M. Romano, L. Diomede, G. Guiso, S. Caccia, C. Perego, M. Salmona

Research output: Contribution to journalArticle

Abstract

Two doses (250 and 1000 mg/kg body weight) of aspartame were administered orally to male rats, and plasma and brain phenylalanine and tyrosine kinetic profiles were studied. In both plasma and brain the maximum increase in phenylalanine and tyrosine levels was reached 60 min after treatment. The changes in brain levels of phenylalanine or tyrosine 0, 60, 120 or 180 min after treatment with 1000 mg AMP/kg were directly correlated with the ratio of the plasma concentration of phenylalanine or tyrosine to the overall plasma concentration of the other large neutral amino acids. The time course of monoamine and metabolite concentrations, in the corpora striatum of the brain, was studied after an oral dose of 500 mg phenylalanine/kg. No significant modifications of monoamine levels were found at any of the times studied, up to 5 hr after dosing.

Original languageEnglish
Pages (from-to)317-321
Number of pages5
JournalFood and Chemical Toxicology
Volume28
Issue number5
DOIs
Publication statusPublished - 1990

ASJC Scopus subject areas

  • Food Science
  • Toxicology

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