Plasma and brain levels of glutamate and pyroglutamate after oral monosodium glutamate to rats

S. Caccia, S. Garattini, P. Ghezzi, M. G. Zanini

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Plasma and brain levels of pyroglutamate (Py), a compound connected with the pathway of glutamate (GA) metabolism, were measured in rats after oral administration of monosodium glutamate (MSG) or Py. Oral MSG (1 g/kg) was followed by only a small rise in plasma Py levels. No increase of Py or GA brain levels was observed in these experimental conditions. Oral administration of Py (0.05, 0.5 and 1 g/kg) resulted in a marked dose-dependent increase of plasma Py, but no increase of plasma or brain GA levels. However, Py accumulated in brain in a doserelated manner. After 0.0 mg/kg the basal brain levels remained unchanged at all the times considered. Rat brain Py levels significantly increased when the oral dose of Py was raised to 0.5 g/kg. Peak brain levels were reached at 240 min, and were about 3 and 4 times the basal levels after 0.5 and 1 g/kg, respectively.

Original languageEnglish
Pages (from-to)169-175
Number of pages7
JournalToxicology Letters
Volume10
Issue number2-3
DOIs
Publication statusPublished - 1982

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Pyrrolidonecarboxylic Acid
Sodium Glutamate
Rats
Glutamic Acid
Brain
Plasmas
Oral Administration
Metabolism

ASJC Scopus subject areas

  • Toxicology

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Plasma and brain levels of glutamate and pyroglutamate after oral monosodium glutamate to rats. / Caccia, S.; Garattini, S.; Ghezzi, P.; Zanini, M. G.

In: Toxicology Letters, Vol. 10, No. 2-3, 1982, p. 169-175.

Research output: Contribution to journalArticle

Caccia, S. ; Garattini, S. ; Ghezzi, P. ; Zanini, M. G. / Plasma and brain levels of glutamate and pyroglutamate after oral monosodium glutamate to rats. In: Toxicology Letters. 1982 ; Vol. 10, No. 2-3. pp. 169-175.
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