Abstract
Altaraura, Alfredo Carlo, Fedele De Novellis, Massimo C. Mauri and Roberto Gomeni: Plasma and brain pharmacokinetics of mianserin after single and multiple dosing in mice. Prog. Neuro-Psychopharmacol. & Biol. Psychiat. 1987, 11: 23-33. 1. 1. Pharmacokinetics parameters describing the time course of concentrations of mianserin (MIA) in plasma and brain and the relationship between plasma and brain concentrations were studied after acute and chronic administration of increasing doses of MIA in adult mice. 2. 2. There was a linear relationship between the area under the curve (AUC), the maximum concentration (Cmax) and doses, in plasma and brain, both during acute and chronic experiments (p <0.05). 3. 3. A five-fold variation in plasma and brain terminal half-life (t 1 2) after chronic administration of the drug was observed, possibly due to a reduction in plasma drug clearance (CL). 4. 4. The values of Cmax and AUC in plasma and brain showed an increase of respectively about three and twelve times after chronic treatment. 5. 5. A very good correlation was observed between plasma and brain Cmax in both acute and chronic experiments; brain Cmax was 10.2 (±0.16) times higher than plasma Cmax after acute administration and 12.08 (± 1.33) times higher after chronic administration.
| Original language | English |
|---|---|
| Pages (from-to) | 23-33 |
| Number of pages | 11 |
| Journal | Progress in Neuro-Psychopharmacology and Biological Psychiatry |
| Volume | 11 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 1987 |
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Keywords
- acute and chronic treatment
- experimental pharmacokinetics
- mianserin
- plasma and brain drug levels
ASJC Scopus subject areas
- Biological Psychiatry
- Pharmacology
Cite this
Plasma and brain pharmacokinetics of mianserin after single and multiple dosing in mice. / Altamura, Alfredo Carlo; De Novellis, Fedele; Mauri, Massimo C.; Gomeni, Roberto.
In: Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 11, No. 1, 1987, p. 23-33.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Plasma and brain pharmacokinetics of mianserin after single and multiple dosing in mice
AU - Altamura, Alfredo Carlo
AU - De Novellis, Fedele
AU - Mauri, Massimo C.
AU - Gomeni, Roberto
PY - 1987
Y1 - 1987
N2 - Altaraura, Alfredo Carlo, Fedele De Novellis, Massimo C. Mauri and Roberto Gomeni: Plasma and brain pharmacokinetics of mianserin after single and multiple dosing in mice. Prog. Neuro-Psychopharmacol. & Biol. Psychiat. 1987, 11: 23-33. 1. 1. Pharmacokinetics parameters describing the time course of concentrations of mianserin (MIA) in plasma and brain and the relationship between plasma and brain concentrations were studied after acute and chronic administration of increasing doses of MIA in adult mice. 2. 2. There was a linear relationship between the area under the curve (AUC), the maximum concentration (Cmax) and doses, in plasma and brain, both during acute and chronic experiments (p <0.05). 3. 3. A five-fold variation in plasma and brain terminal half-life (t 1 2) after chronic administration of the drug was observed, possibly due to a reduction in plasma drug clearance (CL). 4. 4. The values of Cmax and AUC in plasma and brain showed an increase of respectively about three and twelve times after chronic treatment. 5. 5. A very good correlation was observed between plasma and brain Cmax in both acute and chronic experiments; brain Cmax was 10.2 (±0.16) times higher than plasma Cmax after acute administration and 12.08 (± 1.33) times higher after chronic administration.
AB - Altaraura, Alfredo Carlo, Fedele De Novellis, Massimo C. Mauri and Roberto Gomeni: Plasma and brain pharmacokinetics of mianserin after single and multiple dosing in mice. Prog. Neuro-Psychopharmacol. & Biol. Psychiat. 1987, 11: 23-33. 1. 1. Pharmacokinetics parameters describing the time course of concentrations of mianserin (MIA) in plasma and brain and the relationship between plasma and brain concentrations were studied after acute and chronic administration of increasing doses of MIA in adult mice. 2. 2. There was a linear relationship between the area under the curve (AUC), the maximum concentration (Cmax) and doses, in plasma and brain, both during acute and chronic experiments (p <0.05). 3. 3. A five-fold variation in plasma and brain terminal half-life (t 1 2) after chronic administration of the drug was observed, possibly due to a reduction in plasma drug clearance (CL). 4. 4. The values of Cmax and AUC in plasma and brain showed an increase of respectively about three and twelve times after chronic treatment. 5. 5. A very good correlation was observed between plasma and brain Cmax in both acute and chronic experiments; brain Cmax was 10.2 (±0.16) times higher than plasma Cmax after acute administration and 12.08 (± 1.33) times higher after chronic administration.
KW - acute and chronic treatment
KW - experimental pharmacokinetics
KW - mianserin
KW - plasma and brain drug levels
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UR - http://www.scopus.com/inward/citedby.url?scp=0023153805&partnerID=8YFLogxK
U2 - 10.1016/0278-5846(87)90028-5
DO - 10.1016/0278-5846(87)90028-5
M3 - Article
C2 - 3602411
AN - SCOPUS:0023153805
VL - 11
SP - 23
EP - 33
JO - Progress in Neuro-Psychopharmacology and Biological Psychiatry
JF - Progress in Neuro-Psychopharmacology and Biological Psychiatry
SN - 0278-5846
IS - 1
ER -