Plasma and brain pharmacokinetics of mianserin after single and multiple dosing in mice

Alfredo Carlo Altamura, Fedele De Novellis, Massimo C. Mauri, Roberto Gomeni

Research output: Contribution to journalArticle

Abstract

Altaraura, Alfredo Carlo, Fedele De Novellis, Massimo C. Mauri and Roberto Gomeni: Plasma and brain pharmacokinetics of mianserin after single and multiple dosing in mice. Prog. Neuro-Psychopharmacol. & Biol. Psychiat. 1987, 11: 23-33. 1. 1. Pharmacokinetics parameters describing the time course of concentrations of mianserin (MIA) in plasma and brain and the relationship between plasma and brain concentrations were studied after acute and chronic administration of increasing doses of MIA in adult mice. 2. 2. There was a linear relationship between the area under the curve (AUC), the maximum concentration (Cmax) and doses, in plasma and brain, both during acute and chronic experiments (p <0.05). 3. 3. A five-fold variation in plasma and brain terminal half-life (t 1 2) after chronic administration of the drug was observed, possibly due to a reduction in plasma drug clearance (CL). 4. 4. The values of Cmax and AUC in plasma and brain showed an increase of respectively about three and twelve times after chronic treatment. 5. 5. A very good correlation was observed between plasma and brain Cmax in both acute and chronic experiments; brain Cmax was 10.2 (±0.16) times higher than plasma Cmax after acute administration and 12.08 (± 1.33) times higher after chronic administration.

Original languageEnglish
Pages (from-to)23-33
Number of pages11
JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
Volume11
Issue number1
DOIs
Publication statusPublished - 1987

Fingerprint

Mianserin
Pharmacokinetics
Brain
Area Under Curve
Pharmaceutical Preparations
Half-Life

Keywords

  • acute and chronic treatment
  • experimental pharmacokinetics
  • mianserin
  • plasma and brain drug levels

ASJC Scopus subject areas

  • Biological Psychiatry
  • Pharmacology

Cite this

Plasma and brain pharmacokinetics of mianserin after single and multiple dosing in mice. / Altamura, Alfredo Carlo; De Novellis, Fedele; Mauri, Massimo C.; Gomeni, Roberto.

In: Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 11, No. 1, 1987, p. 23-33.

Research output: Contribution to journalArticle

@article{98bcc3537ef74c26a209361d0a330267,
title = "Plasma and brain pharmacokinetics of mianserin after single and multiple dosing in mice",
abstract = "Altaraura, Alfredo Carlo, Fedele De Novellis, Massimo C. Mauri and Roberto Gomeni: Plasma and brain pharmacokinetics of mianserin after single and multiple dosing in mice. Prog. Neuro-Psychopharmacol. & Biol. Psychiat. 1987, 11: 23-33. 1. 1. Pharmacokinetics parameters describing the time course of concentrations of mianserin (MIA) in plasma and brain and the relationship between plasma and brain concentrations were studied after acute and chronic administration of increasing doses of MIA in adult mice. 2. 2. There was a linear relationship between the area under the curve (AUC), the maximum concentration (Cmax) and doses, in plasma and brain, both during acute and chronic experiments (p <0.05). 3. 3. A five-fold variation in plasma and brain terminal half-life (t 1 2) after chronic administration of the drug was observed, possibly due to a reduction in plasma drug clearance (CL). 4. 4. The values of Cmax and AUC in plasma and brain showed an increase of respectively about three and twelve times after chronic treatment. 5. 5. A very good correlation was observed between plasma and brain Cmax in both acute and chronic experiments; brain Cmax was 10.2 (±0.16) times higher than plasma Cmax after acute administration and 12.08 (± 1.33) times higher after chronic administration.",
keywords = "acute and chronic treatment, experimental pharmacokinetics, mianserin, plasma and brain drug levels",
author = "Altamura, {Alfredo Carlo} and {De Novellis}, Fedele and Mauri, {Massimo C.} and Roberto Gomeni",
year = "1987",
doi = "10.1016/0278-5846(87)90028-5",
language = "English",
volume = "11",
pages = "23--33",
journal = "Progress in Neuro-Psychopharmacology and Biological Psychiatry",
issn = "0278-5846",
publisher = "Elsevier Inc.",
number = "1",

}

TY - JOUR

T1 - Plasma and brain pharmacokinetics of mianserin after single and multiple dosing in mice

AU - Altamura, Alfredo Carlo

AU - De Novellis, Fedele

AU - Mauri, Massimo C.

AU - Gomeni, Roberto

PY - 1987

Y1 - 1987

N2 - Altaraura, Alfredo Carlo, Fedele De Novellis, Massimo C. Mauri and Roberto Gomeni: Plasma and brain pharmacokinetics of mianserin after single and multiple dosing in mice. Prog. Neuro-Psychopharmacol. & Biol. Psychiat. 1987, 11: 23-33. 1. 1. Pharmacokinetics parameters describing the time course of concentrations of mianserin (MIA) in plasma and brain and the relationship between plasma and brain concentrations were studied after acute and chronic administration of increasing doses of MIA in adult mice. 2. 2. There was a linear relationship between the area under the curve (AUC), the maximum concentration (Cmax) and doses, in plasma and brain, both during acute and chronic experiments (p <0.05). 3. 3. A five-fold variation in plasma and brain terminal half-life (t 1 2) after chronic administration of the drug was observed, possibly due to a reduction in plasma drug clearance (CL). 4. 4. The values of Cmax and AUC in plasma and brain showed an increase of respectively about three and twelve times after chronic treatment. 5. 5. A very good correlation was observed between plasma and brain Cmax in both acute and chronic experiments; brain Cmax was 10.2 (±0.16) times higher than plasma Cmax after acute administration and 12.08 (± 1.33) times higher after chronic administration.

AB - Altaraura, Alfredo Carlo, Fedele De Novellis, Massimo C. Mauri and Roberto Gomeni: Plasma and brain pharmacokinetics of mianserin after single and multiple dosing in mice. Prog. Neuro-Psychopharmacol. & Biol. Psychiat. 1987, 11: 23-33. 1. 1. Pharmacokinetics parameters describing the time course of concentrations of mianserin (MIA) in plasma and brain and the relationship between plasma and brain concentrations were studied after acute and chronic administration of increasing doses of MIA in adult mice. 2. 2. There was a linear relationship between the area under the curve (AUC), the maximum concentration (Cmax) and doses, in plasma and brain, both during acute and chronic experiments (p <0.05). 3. 3. A five-fold variation in plasma and brain terminal half-life (t 1 2) after chronic administration of the drug was observed, possibly due to a reduction in plasma drug clearance (CL). 4. 4. The values of Cmax and AUC in plasma and brain showed an increase of respectively about three and twelve times after chronic treatment. 5. 5. A very good correlation was observed between plasma and brain Cmax in both acute and chronic experiments; brain Cmax was 10.2 (±0.16) times higher than plasma Cmax after acute administration and 12.08 (± 1.33) times higher after chronic administration.

KW - acute and chronic treatment

KW - experimental pharmacokinetics

KW - mianserin

KW - plasma and brain drug levels

UR - http://www.scopus.com/inward/record.url?scp=0023153805&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023153805&partnerID=8YFLogxK

U2 - 10.1016/0278-5846(87)90028-5

DO - 10.1016/0278-5846(87)90028-5

M3 - Article

C2 - 3602411

AN - SCOPUS:0023153805

VL - 11

SP - 23

EP - 33

JO - Progress in Neuro-Psychopharmacology and Biological Psychiatry

JF - Progress in Neuro-Psychopharmacology and Biological Psychiatry

SN - 0278-5846

IS - 1

ER -