Plasma and brain pharmacokinetics of mianserin after single and multiple dosing in mice

Alfredo Carlo Altamura, Fedele De Novellis, Massimo C. Mauri, Roberto Gomeni

Research output: Contribution to journalArticlepeer-review

Abstract

Altaraura, Alfredo Carlo, Fedele De Novellis, Massimo C. Mauri and Roberto Gomeni: Plasma and brain pharmacokinetics of mianserin after single and multiple dosing in mice. Prog. Neuro-Psychopharmacol. & Biol. Psychiat. 1987, 11: 23-33. 1. 1. Pharmacokinetics parameters describing the time course of concentrations of mianserin (MIA) in plasma and brain and the relationship between plasma and brain concentrations were studied after acute and chronic administration of increasing doses of MIA in adult mice. 2. 2. There was a linear relationship between the area under the curve (AUC), the maximum concentration (Cmax) and doses, in plasma and brain, both during acute and chronic experiments (p <0.05). 3. 3. A five-fold variation in plasma and brain terminal half-life (t 1 2) after chronic administration of the drug was observed, possibly due to a reduction in plasma drug clearance (CL). 4. 4. The values of Cmax and AUC in plasma and brain showed an increase of respectively about three and twelve times after chronic treatment. 5. 5. A very good correlation was observed between plasma and brain Cmax in both acute and chronic experiments; brain Cmax was 10.2 (±0.16) times higher than plasma Cmax after acute administration and 12.08 (± 1.33) times higher after chronic administration.

Original languageEnglish
Pages (from-to)23-33
Number of pages11
JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
Volume11
Issue number1
DOIs
Publication statusPublished - 1987

Keywords

  • acute and chronic treatment
  • experimental pharmacokinetics
  • mianserin
  • plasma and brain drug levels

ASJC Scopus subject areas

  • Biological Psychiatry
  • Pharmacology

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