Plasma and CSF endorphin levels in primary and symptomatic headaches

G. Nappi, F. Facchinetti, E. Martignoni, F. Petraglia, G. Bono, G. Micieli, C. Rosaschino, G. C. Manzoni, A. R. Genazzani

Research output: Contribution to journalArticlepeer-review


The role of opiates in pain perception and neuroendocrine responses to environmental stimuli is well known, so that plasma and CSF endorphin levels may represent useful markers of endogenous analgesia and adaptive body mechanisms. The present study concerns various forms of headache: primary (Common Migraine: CM; Migraine with Interparoxysmal Headache: MIH; Cluster Headache: CH) and symptomatic (Chronic Post Traumatic Headache: CPTH; Ischemic Cerebrovascular Headache: ICVH). A group of age-matched healthy subjects was used as controls (C). The results show a significant decrease of plasma B-EP levels only in MIH patients (p

Original languageEnglish
Pages (from-to)141-144
Number of pages4
Issue number3
Publication statusPublished - 1985

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)


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