Concentrations of isoxicam in the plasma and synovial fluid of 7 patients were investigated by means of high-pressure liquid chromatography. The samples were collected after 7 days' treatment with a single 200 mg isoxicam capsule taken each morning. A highly significant correlation was found (r = 0.82; p <0.05) between isoxicam concentrations in the plasma and in the synovial fluid. The mean concentration (± s.d.) was 25.54 ± 10.91 μg/ml in the plasma and 17.47 ± 6.54 μg/ml in the synovial fluid; the ratio between isoxicam concentrations in the synovial fluid and in the plasma was 71.06% ± 18.83.
|Number of pages||5|
|Journal||Drugs under Experimental and Clinical Research|
|Publication status||Published - 1985|
ASJC Scopus subject areas
- Molecular Medicine
- Pharmacology (medical)
- Drug Discovery