Plasma and synovial fluid concentrations of isoxicam in meniscectomized patients

R. Ballerini, A. Casini, M. Chinol, C. Mannucci, F. Melani, F. Ungar

Research output: Contribution to journalArticle

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Abstract

Concentrations of isoxicam in the plasma and synovial fluid of 7 patients were investigated by means of high-pressure liquid chromatography. The samples were collected after 7 days' treatment with a single 200 mg isoxicam capsule taken each morning. A highly significant correlation was found (r = 0.82; p <0.05) between isoxicam concentrations in the plasma and in the synovial fluid. The mean concentration (± s.d.) was 25.54 ± 10.91 μg/ml in the plasma and 17.47 ± 6.54 μg/ml in the synovial fluid; the ratio between isoxicam concentrations in the synovial fluid and in the plasma was 71.06% ± 18.83.

Original languageEnglish
Pages (from-to)517-521
Number of pages5
JournalDrugs under Experimental and Clinical Research
Volume11
Issue number8
Publication statusPublished - 1985

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Synovial Fluid
Capsules
High Pressure Liquid Chromatography
isoxicam
Therapeutics

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology (medical)
  • Pharmacology
  • Drug Discovery

Cite this

Ballerini, R., Casini, A., Chinol, M., Mannucci, C., Melani, F., & Ungar, F. (1985). Plasma and synovial fluid concentrations of isoxicam in meniscectomized patients. Drugs under Experimental and Clinical Research, 11(8), 517-521.

Plasma and synovial fluid concentrations of isoxicam in meniscectomized patients. / Ballerini, R.; Casini, A.; Chinol, M.; Mannucci, C.; Melani, F.; Ungar, F.

In: Drugs under Experimental and Clinical Research, Vol. 11, No. 8, 1985, p. 517-521.

Research output: Contribution to journalArticle

Ballerini, R, Casini, A, Chinol, M, Mannucci, C, Melani, F & Ungar, F 1985, 'Plasma and synovial fluid concentrations of isoxicam in meniscectomized patients', Drugs under Experimental and Clinical Research, vol. 11, no. 8, pp. 517-521.
Ballerini, R. ; Casini, A. ; Chinol, M. ; Mannucci, C. ; Melani, F. ; Ungar, F. / Plasma and synovial fluid concentrations of isoxicam in meniscectomized patients. In: Drugs under Experimental and Clinical Research. 1985 ; Vol. 11, No. 8. pp. 517-521.
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