Plasma and synovial fluid concentrations of isoxicam in meniscectomized patients

R. Ballerini, A. Casini, M. Chinol, C. Mannucci, F. Melani, F. Ungar

Research output: Contribution to journalArticlepeer-review

Abstract

Concentrations of isoxicam in the plasma and synovial fluid of 7 patients were investigated by means of high-pressure liquid chromatography. The samples were collected after 7 days' treatment with a single 200 mg isoxicam capsule taken each morning. A highly significant correlation was found (r = 0.82; p <0.05) between isoxicam concentrations in the plasma and in the synovial fluid. The mean concentration (± s.d.) was 25.54 ± 10.91 μg/ml in the plasma and 17.47 ± 6.54 μg/ml in the synovial fluid; the ratio between isoxicam concentrations in the synovial fluid and in the plasma was 71.06% ± 18.83.

Original languageEnglish
Pages (from-to)517-521
Number of pages5
JournalDrugs under Experimental and Clinical Research
Volume11
Issue number8
Publication statusPublished - 1985

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology (medical)
  • Pharmacology
  • Drug Discovery

Fingerprint

Dive into the research topics of 'Plasma and synovial fluid concentrations of isoxicam in meniscectomized patients'. Together they form a unique fingerprint.

Cite this