Plasma and urinary GH following a standardized exercise protocol to assess GH production in short children

A. Sartorio, E. Palmieri, V. Vangeli, G. Conte, M. Narici, G. Faglia

Research output: Contribution to journalArticle

Abstract

Plasma and urinary GH responses following acute physical exercise were evaluated in 19 short-statured children (12 males, 7 females, median age: 11.4 yr, age range: 6.1-14.5 yr, Tanner stage I-III, height ≤3rd centile for age; 7 with familial short stature, FSS; 8 with constitutional growth delay, CGD; 4 with GH deficiency, GHD) and 7 normally growing, age- and sex-matched control children (4 males, 3 females, median age 11.0 yr, range: 7.2-13.1 yr, Tanner stage I-III). All patients and controls underwent a standardized exercise protocol (consisting of jogging up and down a corridor for 15 min, strongly encouraged to produce the maximum possible effort, corresponding to 70-80% of the maximal heart rate) after an overnight fasting. Samples for plasma GH determinations were drawn at 0 time (baseline), at 20 min (5 min after the end of exercise) and at 35 min (after 20 min of rest); urine samples were collected before (0 time) and at 40, 80 and 120 min after exercise. The distance covered by children with GHD during the test was significantly lower (p

Original languageEnglish
Pages (from-to)515-521
Number of pages7
JournalJournal of Endocrinological Investigation
Volume24
Issue number7
Publication statusPublished - 2001

Keywords

  • Children
  • GH
  • Physical exercise
  • Short stature

ASJC Scopus subject areas

  • Endocrinology

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