Plasma Androgen Receptor and Docetaxel for Metastatic Castration-resistant Prostate Cancer

Vincenza Conteduca; Anuradha Jayaram; Nuria Romero-Laorden; Daniel Wetterskog; Samanta Salvi; Giorgia Gurioli; Emanuela Scarpi; Elena Castro; Mercedes Marin-Aguilera; Cristian Lolli; Giuseppe Schepisi; Antonio Maugeri; Anna Wingate; Alberto Farolfi; Valentina Casadio; Ana Medina; Javier Puente; Mª José Méndez Vidal; Rafael Morales-Barrera; Jose C. Villa-Guzmán; Susana Hernando; Alejo Rodriguez-Vida; Aránzazu González-del-Alba; Begoña Mellado; Enrique Gonzalez-Billalabeitia; David Olmos; Gerhardt Attard; Ugo De Giorgi

doi:10.1016/j.eururo.2018.09.049

Plasma Androgen Receptor and Docetaxel for Metastatic Castration-resistant Prostate Cancer

Vincenza Conteduca, Anuradha Jayaram, Nuria Romero-Laorden, Daniel Wetterskog, Samanta Salvi, Giorgia Gurioli, Emanuela Scarpi, Elena Castro, Mercedes Marin-Aguilera, Cristian Lolli, Giuseppe Schepisi, Antonio Maugeri, Anna Wingate, Alberto Farolfi, Valentina Casadio, Ana Medina, Javier Puente, Mª José Méndez Vidal, Rafael Morales-Barrera, Jose C. Villa-GuzmánSusana Hernando, Alejo Rodriguez-Vida, Aránzazu González-del-Alba, Begoña Mellado, Enrique Gonzalez-Billalabeitia, David Olmos, Gerhardt Attard, Ugo De Giorgi

Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori

Research output: Contribution to journal › Article

Abstract

Analysis of metastatic castration-resistant prostate cancer (mCRPC) patients receiving first-line therapy showed that plasma androgen receptor (AR)-normal status favored treatment with abiraterone or enzalutamide, whilst docetaxel benefit was unrelated to plasma AR. AR testing in plasma may have clinical utility for treatment selection in mCRPC.

Original language	English
Pages (from-to)	368-373
Number of pages	6
Journal	European Urology
Volume	75
Issue number	3
DOIs	https://doi.org/10.1016/j.eururo.2018.09.049
Publication status	Published - Mar 2019

Keywords

Androgen receptor
Androgen receptor–directed therapies
Biomarker
Castration-resistant prostate cancer
Docetaxel
Plasma DNA

ASJC Scopus subject areas

Urology

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10.1016/j.eururo.2018.09.049

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Conteduca, V., Jayaram, A., Romero-Laorden, N., Wetterskog, D., Salvi, S., Gurioli, G., Scarpi, E., Castro, E., Marin-Aguilera, M., Lolli, C., Schepisi, G., Maugeri, A., Wingate, A., Farolfi, A., Casadio, V., Medina, A., Puente, J., Vidal, M. J. M., Morales-Barrera, R., ... De Giorgi, U. (2019). Plasma Androgen Receptor and Docetaxel for Metastatic Castration-resistant Prostate Cancer. European Urology, 75(3), 368-373. https://doi.org/10.1016/j.eururo.2018.09.049

Plasma Androgen Receptor and Docetaxel for Metastatic Castration-resistant Prostate Cancer. / Conteduca, Vincenza; Jayaram, Anuradha; Romero-Laorden, Nuria; Wetterskog, Daniel; Salvi, Samanta; Gurioli, Giorgia; Scarpi, Emanuela; Castro, Elena; Marin-Aguilera, Mercedes; Lolli, Cristian ; Schepisi, Giuseppe; Maugeri, Antonio; Wingate, Anna; Farolfi, Alberto; Casadio, Valentina; Medina, Ana; Puente, Javier; Vidal, Mª José Méndez; Morales-Barrera, Rafael; Villa-Guzmán, Jose C.; Hernando, Susana; Rodriguez-Vida, Alejo; González-del-Alba, Aránzazu; Mellado, Begoña; Gonzalez-Billalabeitia, Enrique; Olmos, David; Attard, Gerhardt; De Giorgi, Ugo.

In: European Urology, Vol. 75, No. 3, 03.2019, p. 368-373.

Research output: Contribution to journal › Article

Conteduca, V, Jayaram, A, Romero-Laorden, N, Wetterskog, D, Salvi, S, Gurioli, G, Scarpi, E, Castro, E, Marin-Aguilera, M, Lolli, C , Schepisi, G, Maugeri, A, Wingate, A, Farolfi, A, Casadio, V, Medina, A, Puente, J, Vidal, MJM, Morales-Barrera, R, Villa-Guzmán, JC, Hernando, S, Rodriguez-Vida, A, González-del-Alba, A, Mellado, B, Gonzalez-Billalabeitia, E, Olmos, D, Attard, G & De Giorgi, U 2019, 'Plasma Androgen Receptor and Docetaxel for Metastatic Castration-resistant Prostate Cancer', European Urology, vol. 75, no. 3, pp. 368-373. https://doi.org/10.1016/j.eururo.2018.09.049

Conteduca, Vincenza ; Jayaram, Anuradha ; Romero-Laorden, Nuria ; Wetterskog, Daniel ; Salvi, Samanta ; Gurioli, Giorgia ; Scarpi, Emanuela ; Castro, Elena ; Marin-Aguilera, Mercedes ; Lolli, Cristian ; Schepisi, Giuseppe ; Maugeri, Antonio ; Wingate, Anna ; Farolfi, Alberto ; Casadio, Valentina ; Medina, Ana ; Puente, Javier ; Vidal, Mª José Méndez ; Morales-Barrera, Rafael ; Villa-Guzmán, Jose C. ; Hernando, Susana ; Rodriguez-Vida, Alejo ; González-del-Alba, Aránzazu ; Mellado, Begoña ; Gonzalez-Billalabeitia, Enrique ; Olmos, David ; Attard, Gerhardt ; De Giorgi, Ugo. / Plasma Androgen Receptor and Docetaxel for Metastatic Castration-resistant Prostate Cancer. In: European Urology. 2019 ; Vol. 75, No. 3. pp. 368-373.

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abstract = "Analysis of metastatic castration-resistant prostate cancer (mCRPC) patients receiving first-line therapy showed that plasma androgen receptor (AR)-normal status favored treatment with abiraterone or enzalutamide, whilst docetaxel benefit was unrelated to plasma AR. AR testing in plasma may have clinical utility for treatment selection in mCRPC.",

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AU - Jayaram, Anuradha

AU - Romero-Laorden, Nuria

AU - Wetterskog, Daniel

AU - Salvi, Samanta

AU - Gurioli, Giorgia

AU - Scarpi, Emanuela

AU - Castro, Elena

AU - Marin-Aguilera, Mercedes

AU - Lolli, Cristian

AU - Schepisi, Giuseppe

AU - Maugeri, Antonio

AU - Wingate, Anna

AU - Farolfi, Alberto

AU - Casadio, Valentina

AU - Medina, Ana

AU - Puente, Javier

AU - Vidal, Mª José Méndez

AU - Morales-Barrera, Rafael

AU - Villa-Guzmán, Jose C.

AU - Hernando, Susana

AU - Rodriguez-Vida, Alejo

AU - González-del-Alba, Aránzazu

AU - Mellado, Begoña

AU - Gonzalez-Billalabeitia, Enrique

AU - Olmos, David

AU - Attard, Gerhardt

AU - De Giorgi, Ugo

PY - 2019/3

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KW - Androgen receptor–directed therapies

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