Plasma brain natriuretic peptide is a marker of right ventricular overload in pulmonary hypertension associated to HIV infection

Stefano Ghio, Angela Di Matteo, Laura Scelsi, Catherine Klersy, Paolo Orsolini, Lorenzo Monti, Carlo Campana, Lorenzo Minoli, Luigi Tavazzi

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Abstract

The levels of plasma brain natriuretic peptide (BNP) are known to be elevated in patients with primary pulmonary hypertension (PH). We sought to verify the sensitivity and specificity of plasma BNP levels for the diagnosis of PH in HIV infected patients. Plasma N-terminal proBNP levels were measured in 16 patients with HIV disease and a confirmed diagnosis of PH and in 77 control HIV patients with no cardiac or pulmonary disease. All patients underwent an echocardiographic and Doppler examination focused on the evaluation of right ventricular (RV) geometry and function. An abnormal value of N-terminal proBNP (>153 pg/ml in males and >88 pg/ml in females) yielded a 91% specificity and a 81% sensitivity for the diagnosis of PH. Three PH patients with normal N-terminal but similar transtricuspidal and transpulmonary gradients in comparison to those with abnormal N-terminal pro-BNP had normal indices of RV function. Abnormal plasma N-terminal proBNP levels are associated with good sensitivity and specificity to the diagnosis of PH in HIV patients. Normal values of N-terminal proBNP may be observed in PH patients with HIV infection, in the case the right ventricle is not dilated and has a normal systolic function.

Original languageEnglish
JournalEuropean Heart Journal, Supplement
Volume6
Issue number6
DOIs
Publication statusPublished - Nov 2004

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Keywords

  • BNP
  • Echocardiography
  • HIV infection
  • Primary pulmonary hypertension

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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