TY - JOUR
T1 - Plasma carotenoids and vitamin C concentrations and risk of urothelial cell carcinoma in the European Prospective Investigation into Cancer and Nutrition
AU - Ros, Martine M.
AU - Bueno-de-Mesquita, H. Bas
AU - Kampman, Ellen
AU - Aben, Katja K H
AU - Buc̈hner, Frederike L.
AU - Jansen, Eugene H J M
AU - Van Gils, Carla H.
AU - Egevad, Lars
AU - Overvad, Kim
AU - Tjnøneland, Anne
AU - Roswall, Nina
AU - Boutron-Ruault, Marie Christine
AU - Kvaskoff, Marina
AU - Perquier, Florence
AU - Kaaks, Rudolf
AU - Chang-Claude, Jenny
AU - Weikert, Steffen
AU - Boeing, Heiner
AU - Trichopoulou, Antonia
AU - Lagiou, Pagona
AU - Dilis, Vardis
AU - Palli, Domenico
AU - Pala, Valeria
AU - Sacerdote, Carlotta
AU - Tumino, Rosario
AU - Panico, Salvatore
AU - Peeters, Petra H M
AU - Gram, Inger T.
AU - Skeie, Guri
AU - Huerta, José María
AU - Barricarte, Aurelio
AU - Quirós, José Ramón
AU - Sánchez, María José
AU - Buckland, Genevieve
AU - Larrañaga, Nerea
AU - Ehrnström, Roy
AU - Wallström, Peter
AU - Ljungberg, Börje
AU - Hallmans, Göran
AU - Key, Timothy J.
AU - Allen, Naomi E.
AU - Khaw, Kay Tee
AU - Wareham, Nick
AU - Brennan, Paul
AU - Riboli, Elio
AU - Kiemeney, Lambertus A.
PY - 2012/10/1
Y1 - 2012/10/1
N2 - Background: Published associations between dietary carotenoids and vitamin C and bladder cancer risk are inconsistent. Biomarkers may provide more accurate measures of nutrient status. Objective: We investigated the association between plasma carotenoids and vitamin C and risk of urothelial cell carcinoma (UCC) in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition. Design: A total of 856 patients with newly diagnosed UCC were matched with 856 cohort members by sex, age at baseline, study center, date and time of blood collection, and fasting status. Plasma carotenoids (α- and β-carotene, β-cryptoxanthin, lycopene, lutein, and zeaxanthin) were measured by using reverse-phase HPLC, and plasma vitamin C was measured by using a colorimetric assay. Incidence rate ratios (IRRs) were estimated by using conditional logistic regression with adjustment for smoking status, duration, and intensity. Results: UCC risk decreased with higher concentrations of the sum of plasma carotenoids (IRR for the highest compared with the lowest quartile: 0.64; 95% CI: 0.44, 0.93; P-trend = 0.04). Plasma α-carotene was inversely associated with aggressive UCC (IRR: 0.51; 95% CI: 0.30, 0.88; P-trend = 0.02). Plasma lutein was inversely associated with risk of nonaggressive UCC (IRR: 0.56; 95% CI: 0.32, 0.98; P-trend = 0.05). No association was observed between plasma vitamin C and risk of UCC. Conclusions: Although residual confounding by smoking or other factors cannot be excluded, higher concentrations of plasma carotenoids may reduce risk of UCC, in particular aggressive UCC. Plasma lutein may reduce risk of nonaggressive UCC.
AB - Background: Published associations between dietary carotenoids and vitamin C and bladder cancer risk are inconsistent. Biomarkers may provide more accurate measures of nutrient status. Objective: We investigated the association between plasma carotenoids and vitamin C and risk of urothelial cell carcinoma (UCC) in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition. Design: A total of 856 patients with newly diagnosed UCC were matched with 856 cohort members by sex, age at baseline, study center, date and time of blood collection, and fasting status. Plasma carotenoids (α- and β-carotene, β-cryptoxanthin, lycopene, lutein, and zeaxanthin) were measured by using reverse-phase HPLC, and plasma vitamin C was measured by using a colorimetric assay. Incidence rate ratios (IRRs) were estimated by using conditional logistic regression with adjustment for smoking status, duration, and intensity. Results: UCC risk decreased with higher concentrations of the sum of plasma carotenoids (IRR for the highest compared with the lowest quartile: 0.64; 95% CI: 0.44, 0.93; P-trend = 0.04). Plasma α-carotene was inversely associated with aggressive UCC (IRR: 0.51; 95% CI: 0.30, 0.88; P-trend = 0.02). Plasma lutein was inversely associated with risk of nonaggressive UCC (IRR: 0.56; 95% CI: 0.32, 0.98; P-trend = 0.05). No association was observed between plasma vitamin C and risk of UCC. Conclusions: Although residual confounding by smoking or other factors cannot be excluded, higher concentrations of plasma carotenoids may reduce risk of UCC, in particular aggressive UCC. Plasma lutein may reduce risk of nonaggressive UCC.
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U2 - 10.3945/ajcn.111.032920
DO - 10.3945/ajcn.111.032920
M3 - Article
C2 - 22952186
AN - SCOPUS:84866635096
VL - 96
SP - 902
EP - 910
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
SN - 0002-9165
IS - 4
ER -