Il coinvolgimento del rene nelle discrasie plasmacellulari.

Translated title of the contribution: [Plasma cell dyscrasias and renal damage].

Sonia Pasquali, Francesco Iannuzzella, Danio Somenzi, Silvia Mattei, Achiropita Bovino, Mattia Corradini

Research output: Contribution to journalArticlepeer-review


Kidney damage caused by immunoglobulin free light chains in the setting of plasma cell dyscrasias is common and may involve all renal compartments, from the glomerulus to the tubulointerstitium, in a wide variety of histomorphological and clinical patterns. The knowledge of how free light chains can promote kidney injury is growing: they can cause functional changes, be processed and deposited, mediate inflammation, apoptosis and fibrosis, and obstruct nephrons. Each clone of the free light chain is unique and its primary structure and post-translation modification can determine the type of renal disease. Measurement of serum free light chain concentrations and calculation of the serum kappa/lambda ratio, together with renal biopsy, represent essential diagnostic tools. An early and correct diagnosis of renal lesions due to plasma cell dyscrasias will allow early initiation of disease-specific treatment strategies. The treatment of free light chain nephropathies is evolving and knowledge of the pathways that promote renal damage should lead to further therapeutic developments.

Translated title of the contribution[Plasma cell dyscrasias and renal damage].
Original languageItalian
Pages (from-to)58-69
Number of pages12
JournalGiornale italiano di nefrologia : organo ufficiale della Società italiana di nefrologia
Issue number1
Publication statusPublished - Jan 2012

ASJC Scopus subject areas

  • Nephrology


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