Plasma cell granuloma of the thyroid gland: A challenging diagnostic problem

Anna Cremonini, Maurilio Ponzoni, Edoardo Beretta, Gilberto Mari, Maria Giulia Cangi, Gianluigi Arrigoni, Claudio Doglioni

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

This study reports a case of plasma cell granuloma of the thyroid gland in a 47-year-old woman, presenting with a right subhyoid mass and a previous diagnosis of Hashimoto thyroiditis dating back to 1988, which was made on a subtotal thyroidectomy. Plasma cell granuloma preferentially involves the lung, with only 18 cases of thyroid gland involvement having been reported to date in the English literature. Thyroid plasma cell granuloma preferentially affects women and classically shows a prominent plasma cell infiltrate embedded in a variable degree of fibrous stroma: only 2 of the reported cases exhibited the morphologic features of inflammatory myofibroblastic tumor. These morphologic features may raise problems in the differential diagnosis with other plasma cell-rich disorders, including infectious diseases and auto(dys)immune conditions, including the recently described "IgG4-related sclerosing disease." In view of these considerations, a contemporary diagnostic approach to thyroid plasma cell granuloma is therefore discussed here.

Original languageEnglish
Pages (from-to)500-506
Number of pages7
JournalInternational Journal of Surgical Pathology
Volume20
Issue number5
DOIs
Publication statusPublished - Oct 2012

Fingerprint

Plasma Cell Granuloma
Thyroid Gland
Plasma Cells
Literature
Hashimoto Disease
Thyroidectomy
Communicable Diseases
Differential Diagnosis
Immunoglobulin G
Lung
Neoplasms

Keywords

  • IgG4-related disease
  • inflammatory myofibrofibroblastic tumor
  • plasma cell granuloma
  • thyroid

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine
  • Surgery

Cite this

Plasma cell granuloma of the thyroid gland : A challenging diagnostic problem. / Cremonini, Anna; Ponzoni, Maurilio; Beretta, Edoardo; Mari, Gilberto; Cangi, Maria Giulia; Arrigoni, Gianluigi; Doglioni, Claudio.

In: International Journal of Surgical Pathology, Vol. 20, No. 5, 10.2012, p. 500-506.

Research output: Contribution to journalArticle

Cremonini, Anna ; Ponzoni, Maurilio ; Beretta, Edoardo ; Mari, Gilberto ; Cangi, Maria Giulia ; Arrigoni, Gianluigi ; Doglioni, Claudio. / Plasma cell granuloma of the thyroid gland : A challenging diagnostic problem. In: International Journal of Surgical Pathology. 2012 ; Vol. 20, No. 5. pp. 500-506.
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