Plasma clearance and effects of α-hANP infused in patients with end-stage renal failure

G. Tonolo, M. McMillan, J. Polonia, A. Pazzola, P. Montorsi, A. Soro, N. Glorioso, M. A. Richards

Research output: Contribution to journalArticle

Abstract

The effects and clearance of synthetic atrial natriuretic peptide (α-hANP) were investigated in eight patients with end-stage renal failure and six normal volunteers. ANP or vehicle was infused for 1 h at 10 pmol·kg-1·min-1 in random order on two separate occasions. During ANP infusions in end-stage renal patients, microhematocrit rose by 9.8 ± 2% (P <0.005, n = 8), from base-line values of 0.24 ± 0.02. Serum protein and albumin rose consistently. In contrast, during placebo infusions, no significant changes were seen. Blood pressure, heart rate, plasma renin concentration, serum creatinine, and electrolytes did not change significantly during either study phase. In end-stage renal failure patients, metabolic clearance rate of infused ANP was 1.04 ± 0.095 l/min and its plasma half-life was 4 min 34 s. In normal volunteers, metabolic clearance rate was 2.6 l/min and its plasma half-life 3 min 30 s. The data suggest that ANP promotes contraction of plasma volume via a mechanism independent of renal function and also indicate that the kidney is not the only organ involved in the ANP metabolism.

Original languageEnglish
JournalAmerican Journal of Physiology - Renal Fluid and Electrolyte Physiology
Volume254
Issue number6
Publication statusPublished - 1988

Fingerprint

Atrial Natriuretic Factor
Chronic Kidney Failure
Metabolic Clearance Rate
Kidney
Half-Life
Healthy Volunteers
Plasma Volume
Renin
Serum Albumin
Electrolytes
Blood Proteins
Creatinine
Heart Rate
Placebos
Blood Pressure
Serum

ASJC Scopus subject areas

  • Physiology

Cite this

Plasma clearance and effects of α-hANP infused in patients with end-stage renal failure. / Tonolo, G.; McMillan, M.; Polonia, J.; Pazzola, A.; Montorsi, P.; Soro, A.; Glorioso, N.; Richards, M. A.

In: American Journal of Physiology - Renal Fluid and Electrolyte Physiology, Vol. 254, No. 6, 1988.

Research output: Contribution to journalArticle

Tonolo, G. ; McMillan, M. ; Polonia, J. ; Pazzola, A. ; Montorsi, P. ; Soro, A. ; Glorioso, N. ; Richards, M. A. / Plasma clearance and effects of α-hANP infused in patients with end-stage renal failure. In: American Journal of Physiology - Renal Fluid and Electrolyte Physiology. 1988 ; Vol. 254, No. 6.
@article{296619ea379f449ebf3f7a41e56a6f9d,
title = "Plasma clearance and effects of α-hANP infused in patients with end-stage renal failure",
abstract = "The effects and clearance of synthetic atrial natriuretic peptide (α-hANP) were investigated in eight patients with end-stage renal failure and six normal volunteers. ANP or vehicle was infused for 1 h at 10 pmol·kg-1·min-1 in random order on two separate occasions. During ANP infusions in end-stage renal patients, microhematocrit rose by 9.8 ± 2{\%} (P <0.005, n = 8), from base-line values of 0.24 ± 0.02. Serum protein and albumin rose consistently. In contrast, during placebo infusions, no significant changes were seen. Blood pressure, heart rate, plasma renin concentration, serum creatinine, and electrolytes did not change significantly during either study phase. In end-stage renal failure patients, metabolic clearance rate of infused ANP was 1.04 ± 0.095 l/min and its plasma half-life was 4 min 34 s. In normal volunteers, metabolic clearance rate was 2.6 l/min and its plasma half-life 3 min 30 s. The data suggest that ANP promotes contraction of plasma volume via a mechanism independent of renal function and also indicate that the kidney is not the only organ involved in the ANP metabolism.",
author = "G. Tonolo and M. McMillan and J. Polonia and A. Pazzola and P. Montorsi and A. Soro and N. Glorioso and Richards, {M. A.}",
year = "1988",
language = "English",
volume = "254",
journal = "American Journal of Physiology",
issn = "0363-6119",
publisher = "American Physiological Society",
number = "6",

}

TY - JOUR

T1 - Plasma clearance and effects of α-hANP infused in patients with end-stage renal failure

AU - Tonolo, G.

AU - McMillan, M.

AU - Polonia, J.

AU - Pazzola, A.

AU - Montorsi, P.

AU - Soro, A.

AU - Glorioso, N.

AU - Richards, M. A.

PY - 1988

Y1 - 1988

N2 - The effects and clearance of synthetic atrial natriuretic peptide (α-hANP) were investigated in eight patients with end-stage renal failure and six normal volunteers. ANP or vehicle was infused for 1 h at 10 pmol·kg-1·min-1 in random order on two separate occasions. During ANP infusions in end-stage renal patients, microhematocrit rose by 9.8 ± 2% (P <0.005, n = 8), from base-line values of 0.24 ± 0.02. Serum protein and albumin rose consistently. In contrast, during placebo infusions, no significant changes were seen. Blood pressure, heart rate, plasma renin concentration, serum creatinine, and electrolytes did not change significantly during either study phase. In end-stage renal failure patients, metabolic clearance rate of infused ANP was 1.04 ± 0.095 l/min and its plasma half-life was 4 min 34 s. In normal volunteers, metabolic clearance rate was 2.6 l/min and its plasma half-life 3 min 30 s. The data suggest that ANP promotes contraction of plasma volume via a mechanism independent of renal function and also indicate that the kidney is not the only organ involved in the ANP metabolism.

AB - The effects and clearance of synthetic atrial natriuretic peptide (α-hANP) were investigated in eight patients with end-stage renal failure and six normal volunteers. ANP or vehicle was infused for 1 h at 10 pmol·kg-1·min-1 in random order on two separate occasions. During ANP infusions in end-stage renal patients, microhematocrit rose by 9.8 ± 2% (P <0.005, n = 8), from base-line values of 0.24 ± 0.02. Serum protein and albumin rose consistently. In contrast, during placebo infusions, no significant changes were seen. Blood pressure, heart rate, plasma renin concentration, serum creatinine, and electrolytes did not change significantly during either study phase. In end-stage renal failure patients, metabolic clearance rate of infused ANP was 1.04 ± 0.095 l/min and its plasma half-life was 4 min 34 s. In normal volunteers, metabolic clearance rate was 2.6 l/min and its plasma half-life 3 min 30 s. The data suggest that ANP promotes contraction of plasma volume via a mechanism independent of renal function and also indicate that the kidney is not the only organ involved in the ANP metabolism.

UR - http://www.scopus.com/inward/record.url?scp=0023902681&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023902681&partnerID=8YFLogxK

M3 - Article

C2 - 2968052

AN - SCOPUS:0023902681

VL - 254

JO - American Journal of Physiology

JF - American Journal of Physiology

SN - 0363-6119

IS - 6

ER -