Plasma concentrations of angiogenetic factors and angiogenetic inhibitors in patients with ductal pancreatic neoplasms. A pilot study

Raffaele Pezzilli, Dario Fabbri, Massimiliano M. Corsi, Andrea Imbrogno, Alessandra Barassi, Antonio M. Morselli-Labate, Giada Dogliotti, Riccardo Casadei, Roberto Corinaldesi, Gianvico Melzi D'Eril

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The aim of the study was to evaluate the circulating concentrations of vascular endothelial growth factor (VEGF), vascular endothelial growth factor receptor-2 (VEGFR-2), vascular endothelial growth factor-D (VEGF-D) and endostatin in patients with intraductal papillary mucinous neoplasm (IPMN), and in those with ductal adenocarcinomas. Methods: Sixty patients (32 males, 28 females, mean age 69.3±11.3 years) were enrolled: 31 (51.7%) had IPMNs and 29 (48.3%) had histologically confirmed pancreatic adenocarcinomas. Thirty blood donors were also studied as controls. In all study subjects, the concentrations of VEGF, VEGF-D, VEGFR-2, and endostatin were determined using enzyme-linked immunosorbent assays. Results: Serum concentrations of VEGF, VEGF-D, and VEGFR-2 were significantly higher in patients with pancreatic ductal adenocarcinoma and those with IPMNs compared with healthy subjects, while endostatin was significantly higher only in patients with pancreatic ductal adenocarcinoma compared with healthy subjects. Within the group of patients, VEGFR-2 was significantly higher in patients with ductal adenocarcinoma compared to those with IPMNs. The sensitivity and the specificity of VEGFR-2 in differentiating patients with ductal adenocarcinomas from those with IPMN at a cut-off range of 4003-4034 pg/mL was 86.2% and 54.8%, respectively. Conclusions: IPMNs have serum VEGFR-2 concentra-tions different from those in patients with ductal adenocarcinomas. However, serum VEGFR-2 cannot be routinely utilized to differentiate IPMNs from pancreatic ductal adenocarcinomas.

Original languageEnglish
Pages (from-to)1047-1051
Number of pages5
JournalClinical Chemistry and Laboratory Medicine
Volume49
Issue number6
DOIs
Publication statusPublished - Jun 1 2011

Keywords

  • angiogenesis inducing agents
  • endostatins
  • pancreatic neoplasms
  • vascular endothelial growth factor receptor-2

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical

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