Plasma Concentrations of Carbamazepine and Carbamazepine 10,11-Epoxide During Pregnancy and After Delivery

Dina Battino, S. Binelli, L. Bossi, R. Canger, D. Croci, C. Cusi, M. De Giambattista, G. Avanzini

Research output: Contribution to journalArticlepeer-review

Abstract

Plasma concentrations of carbamazepine were monitored in 9 pregnant epileptic patients treated with the drug alone at constant doses during pregnancy and for at least 3 months after delivery. In addition, plasma concentrations of the metabolite, carbamazepine 10,11-epoxide were measured in 6 of the 9 patients. Plasma carbamazepine concentrations were fairly stable during pregnancy, and carbamazepine relative plasma clearances were significantly higher in weeks 4 to 24 than in weeks 25 to 52. After the end of the second trimester, there were no variations in plasma carbamazepine 10,11-epoxide concentrations and carbamazepine 10.11-epoxide: carbamazepine ratios. Both parameters were significantly higher in weeks 4 to 24 than in weeks 25 to 32 of pregnancy.

Original languageEnglish
Pages (from-to)279-284
Number of pages6
JournalClinical Pharmacokinetics
Volume10
Issue number3
DOIs
Publication statusPublished - 1985

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology
  • Pharmacology, Toxicology and Pharmaceutics(all)

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