Plasma Concentrations of Carbamazepine and Carbamazepine 10,11-Epoxide During Pregnancy and After Delivery

Dina Battino, S. Binelli, L. Bossi, R. Canger, D. Croci, C. Cusi, M. De Giambattista, G. Avanzini

Research output: Contribution to journalArticle

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Abstract

Plasma concentrations of carbamazepine were monitored in 9 pregnant epileptic patients treated with the drug alone at constant doses during pregnancy and for at least 3 months after delivery. In addition, plasma concentrations of the metabolite, carbamazepine 10,11-epoxide were measured in 6 of the 9 patients. Plasma carbamazepine concentrations were fairly stable during pregnancy, and carbamazepine relative plasma clearances were significantly higher in weeks 4 to 24 than in weeks 25 to 52. After the end of the second trimester, there were no variations in plasma carbamazepine 10,11-epoxide concentrations and carbamazepine 10.11-epoxide: carbamazepine ratios. Both parameters were significantly higher in weeks 4 to 24 than in weeks 25 to 32 of pregnancy.

Original languageEnglish
Pages (from-to)279-284
Number of pages6
JournalClinical Pharmacokinetics
Volume10
Issue number3
DOIs
Publication statusPublished - 1985

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Carbamazepine
Pregnancy
Second Pregnancy Trimester
carbamazepine epoxide
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Plasma Concentrations of Carbamazepine and Carbamazepine 10,11-Epoxide During Pregnancy and After Delivery. / Battino, Dina; Binelli, S.; Bossi, L.; Canger, R.; Croci, D.; Cusi, C.; De Giambattista, M.; Avanzini, G.

In: Clinical Pharmacokinetics, Vol. 10, No. 3, 1985, p. 279-284.

Research output: Contribution to journalArticle

Battino, Dina ; Binelli, S. ; Bossi, L. ; Canger, R. ; Croci, D. ; Cusi, C. ; De Giambattista, M. ; Avanzini, G. / Plasma Concentrations of Carbamazepine and Carbamazepine 10,11-Epoxide During Pregnancy and After Delivery. In: Clinical Pharmacokinetics. 1985 ; Vol. 10, No. 3. pp. 279-284.
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