Plasma Cortisol response to ACTH does not accurately indicate the state of hypothalamic-pituitary-adrenal axis

E. Reschini, A. Catania, G. Giustina

Research output: Contribution to journalArticlepeer-review

Abstract

The hypothalamic-pituitary-adrenal function was studied in 55 patients with various pituitary disorders. In particular, the consistency between the responses of plasma Cortisol to exogenous ACTH and to insulin hypoglycemia was investigated in 5 patients in whom Cortisol response to insulin was absent; four of these patients showed a Cortisol response to ACTH of variable degree. These 4 patients had surgical or functional hypothalamus-pituitary disconnection and showed a preserved Cortisol response to lysine vasopressin. These data demonstrate the unreliability of ACTH test in assessing hypothalamic-pituitary-adrenal function in hypopituitary patients.

Original languageEnglish
Pages (from-to)259-261
Number of pages3
JournalJournal of Endocrinological Investigation
Volume5
Issue number4
DOIs
Publication statusPublished - 1982

Keywords

  • ACTH
  • adrenal insufficiency
  • Cortisol
  • hypopituitarism
  • insulin hypoglycemia

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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