Plasma cyclic nucleotide levels in acute leukemia patients

M. Peracchi, V. Toschi, F. Bamonti-Catena, L. Lombardi, B. Bareggi, A. Cortelezzi, M. Colombi, A. T. Maiolo, E. E. Polli

Research output: Contribution to journalArticle

Abstract

To verify the clinical usefulness of extracellular cyclic nucleotide determination as a tumor marker, plasma cyclic AMP (cAMP) and cyclic GMP (cGMP) levels were measured in 70 normal subjects and 173 acute leukemia patients studied in different stages of their disease. Mean plasma cAMP levels were similar in leukemic and normal subjects, although in 48 patients in the active stage of the disease, first diagnosis, or relapse, the cAMP values were below the normal range, and most of these patients failed to respond to chemotherapy. Plasma cGMP levels were markedly elevated in untreated patients, normalized in all patients who attained complete remission, and increased promptly to pretreatment values in patients who relapsed, suggesting that their determination may be useful to monitor the patients' response to treatment.

Original languageEnglish
Pages (from-to)1613-1616
Number of pages4
JournalBlood
Volume69
Issue number6
Publication statusPublished - 1987

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Cyclic Nucleotides
Cyclic AMP
Leukemia
Cyclic GMP
Plasmas
Chemotherapy
Tumor Biomarkers
Reference Values
Recurrence
Drug Therapy

ASJC Scopus subject areas

  • Hematology

Cite this

Peracchi, M., Toschi, V., Bamonti-Catena, F., Lombardi, L., Bareggi, B., Cortelezzi, A., ... Polli, E. E. (1987). Plasma cyclic nucleotide levels in acute leukemia patients. Blood, 69(6), 1613-1616.

Plasma cyclic nucleotide levels in acute leukemia patients. / Peracchi, M.; Toschi, V.; Bamonti-Catena, F.; Lombardi, L.; Bareggi, B.; Cortelezzi, A.; Colombi, M.; Maiolo, A. T.; Polli, E. E.

In: Blood, Vol. 69, No. 6, 1987, p. 1613-1616.

Research output: Contribution to journalArticle

Peracchi, M, Toschi, V, Bamonti-Catena, F, Lombardi, L, Bareggi, B, Cortelezzi, A, Colombi, M, Maiolo, AT & Polli, EE 1987, 'Plasma cyclic nucleotide levels in acute leukemia patients', Blood, vol. 69, no. 6, pp. 1613-1616.
Peracchi M, Toschi V, Bamonti-Catena F, Lombardi L, Bareggi B, Cortelezzi A et al. Plasma cyclic nucleotide levels in acute leukemia patients. Blood. 1987;69(6):1613-1616.
Peracchi, M. ; Toschi, V. ; Bamonti-Catena, F. ; Lombardi, L. ; Bareggi, B. ; Cortelezzi, A. ; Colombi, M. ; Maiolo, A. T. ; Polli, E. E. / Plasma cyclic nucleotide levels in acute leukemia patients. In: Blood. 1987 ; Vol. 69, No. 6. pp. 1613-1616.
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