Abstract
To investigate the possibility that a proliferative non-neoplastic process influences extracellular cyclic nucleotide concentrations, we measured plasma cyclic AMP and cyclic GMP levels in 38 patients with homozygous beta-thalassaemia. This group consisted of 20 patients with thalassaemia major transfused regularly (mean pre transfusion Hb levels, 11 g/dl), and 18 patients with thalassaemia intermedia who did not require regular blood transfusion (mean Hb levels 8.7 g/dl). In the patient group, plasma cyclic AMP levels were similar to those of 37 normal subjects matched for age and sex, whereas plasma cyclic GMP levels were markedly higher. Moreover, in the thalassaemic patients there was a significant negative correlation between plasma cyclic GMP levels and haemoglobin concentrations, suggesting that their marked erythroid hyperplasia may play a role in determining alterations in extracellular cyclic GMP levels.
| Original language | English |
|---|---|
| Pages (from-to) | 348-352 |
| Number of pages | 5 |
| Journal | Scandinavian Journal of Haematology |
| Volume | 34 |
| Issue number | 4 |
| Publication status | Published - 1985 |
Fingerprint
ASJC Scopus subject areas
- Hematology
Cite this
Plasma cyclic nucleotide levels in patients with homozygous beta-thalassaemia. / Peracchi, M.; Toschi, V.; Lombardi, L.; Bamonti-Catena, F.; Maiolo, A. T.; Bareggi, B.; Massaro, P.; Polli, E. E.
In: Scandinavian Journal of Haematology, Vol. 34, No. 4, 1985, p. 348-352.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Plasma cyclic nucleotide levels in patients with homozygous beta-thalassaemia
AU - Peracchi, M.
AU - Toschi, V.
AU - Lombardi, L.
AU - Bamonti-Catena, F.
AU - Maiolo, A. T.
AU - Bareggi, B.
AU - Massaro, P.
AU - Polli, E. E.
PY - 1985
Y1 - 1985
N2 - To investigate the possibility that a proliferative non-neoplastic process influences extracellular cyclic nucleotide concentrations, we measured plasma cyclic AMP and cyclic GMP levels in 38 patients with homozygous beta-thalassaemia. This group consisted of 20 patients with thalassaemia major transfused regularly (mean pre transfusion Hb levels, 11 g/dl), and 18 patients with thalassaemia intermedia who did not require regular blood transfusion (mean Hb levels 8.7 g/dl). In the patient group, plasma cyclic AMP levels were similar to those of 37 normal subjects matched for age and sex, whereas plasma cyclic GMP levels were markedly higher. Moreover, in the thalassaemic patients there was a significant negative correlation between plasma cyclic GMP levels and haemoglobin concentrations, suggesting that their marked erythroid hyperplasia may play a role in determining alterations in extracellular cyclic GMP levels.
AB - To investigate the possibility that a proliferative non-neoplastic process influences extracellular cyclic nucleotide concentrations, we measured plasma cyclic AMP and cyclic GMP levels in 38 patients with homozygous beta-thalassaemia. This group consisted of 20 patients with thalassaemia major transfused regularly (mean pre transfusion Hb levels, 11 g/dl), and 18 patients with thalassaemia intermedia who did not require regular blood transfusion (mean Hb levels 8.7 g/dl). In the patient group, plasma cyclic AMP levels were similar to those of 37 normal subjects matched for age and sex, whereas plasma cyclic GMP levels were markedly higher. Moreover, in the thalassaemic patients there was a significant negative correlation between plasma cyclic GMP levels and haemoglobin concentrations, suggesting that their marked erythroid hyperplasia may play a role in determining alterations in extracellular cyclic GMP levels.
UR - http://www.scopus.com/inward/record.url?scp=0021912307&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0021912307&partnerID=8YFLogxK
M3 - Article
C2 - 2988112
AN - SCOPUS:0021912307
VL - 34
SP - 348
EP - 352
JO - European Journal of Haematology
JF - European Journal of Haematology
SN - 0902-4441
IS - 4
ER -