Plasma cytokine profiles in patients with celiac disease and selective IgA deficiency

Francesco Cataldo, Domenico Lio, Vincenzo Marino, Letizia Scola, Antonio Crivello, G. R. Corazza, C. Catassi, E. Fabiani, M. Baldassarre, L. Corvaglia, M. Spina, L. Pensabene, S. Brusa, T. Gentile, G. Barera, C. Bianchi, F. Rea, M. A. Trippiedi, P. Greco, A. Di SabatinoA. M. Pelli, M. Bonamico, M. Barbato, F. Viola, E. Thanasi, A. M. Ambruzzi, M. R. D'Altilia, S. Musumeci, C. Barbera, L. Bramante, C. Sategna-Guidetti, [No Value] Martellossi, A. Ventura

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Celiac disease (CD) and selective IgA deficiency (IgAD) are frequently associated, and share the same genetic background. The aim of the present study was to evaluate both Type 1 and 2 plasma cytokine levels in CD and in CD-IgAD. IL-2, TNF-α, IL-10, IL-4 and IL-13 plasma levels were measured both at diagnosis and after a gluten-free diet (GFD) in 32 CD patients, in 27 CD-IgAD patients and in 30 healthy controls. IFN-γ levels were significantly higher in CD and CD-IgAD than in controls, TNF-α displayed significantly higher levels in CD-IgAD when compared both with controls and with CD, and IL-2 was in CD-IgAD significantly increased respect to controls. Kinetics of the Type 1 cytokine plasma levels did not show a clear relationship with the GFD in both groups of CD patients, and particularly in those with IgAD. IL-4 and IL-13, both at diagnosis and after a GFD, were not significantly different in controls and in celiac patients (with and without IgAD). IL-10, whose production is stimulated by the TNF-α, had significantly higher plasma levels in CD-IgAD, but not in CD patients, with a significant decrease after a GFD. CD and especially CD-IgAD patients display persistently higher pro-inflammatory cytokine levels, suggesting a persistent state of activation of pro-phlogistic signals in CD, particularly when IgAD coexists. Serial measurement of serum IL-10 may be an adjunctive evaluating criterion in the follow-up of CD-IgAD patients.

Original languageEnglish
Pages (from-to)320-324
Number of pages5
JournalPediatric Allergy and Immunology
Volume14
Issue number4
DOIs
Publication statusPublished - Aug 2003

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IgA Deficiency
Celiac Disease
Cytokines
Gluten-Free Diet
Interleukin-10
Interleukin-13
Interleukin-4
Interleukin-2

Keywords

  • Celiac disease
  • Cytokine plasma levels, selective IgA deficiency

ASJC Scopus subject areas

  • Immunology and Allergy
  • Pediatrics, Perinatology, and Child Health
  • Immunology

Cite this

Plasma cytokine profiles in patients with celiac disease and selective IgA deficiency. / Cataldo, Francesco; Lio, Domenico; Marino, Vincenzo; Scola, Letizia; Crivello, Antonio; Corazza, G. R.; Catassi, C.; Fabiani, E.; Baldassarre, M.; Corvaglia, L.; Spina, M.; Pensabene, L.; Brusa, S.; Gentile, T.; Barera, G.; Bianchi, C.; Rea, F.; Trippiedi, M. A.; Greco, P.; Di Sabatino, A.; Pelli, A. M.; Bonamico, M.; Barbato, M.; Viola, F.; Thanasi, E.; Ambruzzi, A. M.; D'Altilia, M. R.; Musumeci, S.; Barbera, C.; Bramante, L.; Sategna-Guidetti, C.; Martellossi, [No Value]; Ventura, A.

In: Pediatric Allergy and Immunology, Vol. 14, No. 4, 08.2003, p. 320-324.

Research output: Contribution to journalArticle

Cataldo, F, Lio, D, Marino, V, Scola, L, Crivello, A, Corazza, GR, Catassi, C, Fabiani, E, Baldassarre, M, Corvaglia, L, Spina, M, Pensabene, L, Brusa, S, Gentile, T, Barera, G, Bianchi, C, Rea, F, Trippiedi, MA, Greco, P, Di Sabatino, A, Pelli, AM, Bonamico, M, Barbato, M, Viola, F, Thanasi, E, Ambruzzi, AM, D'Altilia, MR, Musumeci, S, Barbera, C, Bramante, L, Sategna-Guidetti, C, Martellossi, NV & Ventura, A 2003, 'Plasma cytokine profiles in patients with celiac disease and selective IgA deficiency', Pediatric Allergy and Immunology, vol. 14, no. 4, pp. 320-324. https://doi.org/10.1034/j.1399-3038.2003.00053.x
Cataldo, Francesco ; Lio, Domenico ; Marino, Vincenzo ; Scola, Letizia ; Crivello, Antonio ; Corazza, G. R. ; Catassi, C. ; Fabiani, E. ; Baldassarre, M. ; Corvaglia, L. ; Spina, M. ; Pensabene, L. ; Brusa, S. ; Gentile, T. ; Barera, G. ; Bianchi, C. ; Rea, F. ; Trippiedi, M. A. ; Greco, P. ; Di Sabatino, A. ; Pelli, A. M. ; Bonamico, M. ; Barbato, M. ; Viola, F. ; Thanasi, E. ; Ambruzzi, A. M. ; D'Altilia, M. R. ; Musumeci, S. ; Barbera, C. ; Bramante, L. ; Sategna-Guidetti, C. ; Martellossi, [No Value] ; Ventura, A. / Plasma cytokine profiles in patients with celiac disease and selective IgA deficiency. In: Pediatric Allergy and Immunology. 2003 ; Vol. 14, No. 4. pp. 320-324.
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AU - Lio, Domenico

AU - Marino, Vincenzo

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AU - Crivello, Antonio

AU - Corazza, G. R.

AU - Catassi, C.

AU - Fabiani, E.

AU - Baldassarre, M.

AU - Corvaglia, L.

AU - Spina, M.

AU - Pensabene, L.

AU - Brusa, S.

AU - Gentile, T.

AU - Barera, G.

AU - Bianchi, C.

AU - Rea, F.

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AU - Greco, P.

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AU - Pelli, A. M.

AU - Bonamico, M.

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AU - Viola, F.

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AU - Musumeci, S.

AU - Barbera, C.

AU - Bramante, L.

AU - Sategna-Guidetti, C.

AU - Martellossi, [No Value]

AU - Ventura, A.

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N2 - Celiac disease (CD) and selective IgA deficiency (IgAD) are frequently associated, and share the same genetic background. The aim of the present study was to evaluate both Type 1 and 2 plasma cytokine levels in CD and in CD-IgAD. IL-2, TNF-α, IL-10, IL-4 and IL-13 plasma levels were measured both at diagnosis and after a gluten-free diet (GFD) in 32 CD patients, in 27 CD-IgAD patients and in 30 healthy controls. IFN-γ levels were significantly higher in CD and CD-IgAD than in controls, TNF-α displayed significantly higher levels in CD-IgAD when compared both with controls and with CD, and IL-2 was in CD-IgAD significantly increased respect to controls. Kinetics of the Type 1 cytokine plasma levels did not show a clear relationship with the GFD in both groups of CD patients, and particularly in those with IgAD. IL-4 and IL-13, both at diagnosis and after a GFD, were not significantly different in controls and in celiac patients (with and without IgAD). IL-10, whose production is stimulated by the TNF-α, had significantly higher plasma levels in CD-IgAD, but not in CD patients, with a significant decrease after a GFD. CD and especially CD-IgAD patients display persistently higher pro-inflammatory cytokine levels, suggesting a persistent state of activation of pro-phlogistic signals in CD, particularly when IgAD coexists. Serial measurement of serum IL-10 may be an adjunctive evaluating criterion in the follow-up of CD-IgAD patients.

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