Abstract
Celiac disease (CD) and selective IgA deficiency (IgAD) are frequently associated, and share the same genetic background. The aim of the present study was to evaluate both Type 1 and 2 plasma cytokine levels in CD and in CD-IgAD. IL-2, TNF-α, IL-10, IL-4 and IL-13 plasma levels were measured both at diagnosis and after a gluten-free diet (GFD) in 32 CD patients, in 27 CD-IgAD patients and in 30 healthy controls. IFN-γ levels were significantly higher in CD and CD-IgAD than in controls, TNF-α displayed significantly higher levels in CD-IgAD when compared both with controls and with CD, and IL-2 was in CD-IgAD significantly increased respect to controls. Kinetics of the Type 1 cytokine plasma levels did not show a clear relationship with the GFD in both groups of CD patients, and particularly in those with IgAD. IL-4 and IL-13, both at diagnosis and after a GFD, were not significantly different in controls and in celiac patients (with and without IgAD). IL-10, whose production is stimulated by the TNF-α, had significantly higher plasma levels in CD-IgAD, but not in CD patients, with a significant decrease after a GFD. CD and especially CD-IgAD patients display persistently higher pro-inflammatory cytokine levels, suggesting a persistent state of activation of pro-phlogistic signals in CD, particularly when IgAD coexists. Serial measurement of serum IL-10 may be an adjunctive evaluating criterion in the follow-up of CD-IgAD patients.
| Original language | English |
|---|---|
| Pages (from-to) | 320-324 |
| Number of pages | 5 |
| Journal | Pediatric Allergy and Immunology |
| Volume | 14 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Aug 2003 |
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Keywords
- Celiac disease
- Cytokine plasma levels, selective IgA deficiency
ASJC Scopus subject areas
- Immunology and Allergy
- Pediatrics, Perinatology, and Child Health
- Immunology
Cite this
Plasma cytokine profiles in patients with celiac disease and selective IgA deficiency. / Cataldo, Francesco; Lio, Domenico; Marino, Vincenzo; Scola, Letizia; Crivello, Antonio; Corazza, G. R.; Catassi, C.; Fabiani, E.; Baldassarre, M.; Corvaglia, L.; Spina, M.; Pensabene, L.; Brusa, S.; Gentile, T.; Barera, G.; Bianchi, C.; Rea, F.; Trippiedi, M. A.; Greco, P.; Di Sabatino, A.; Pelli, A. M.; Bonamico, M.; Barbato, M.; Viola, F.; Thanasi, E.; Ambruzzi, A. M.; D'Altilia, M. R.; Musumeci, S.; Barbera, C.; Bramante, L.; Sategna-Guidetti, C.; Martellossi, [No Value]; Ventura, A.
In: Pediatric Allergy and Immunology, Vol. 14, No. 4, 08.2003, p. 320-324.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Plasma cytokine profiles in patients with celiac disease and selective IgA deficiency
AU - Cataldo, Francesco
AU - Lio, Domenico
AU - Marino, Vincenzo
AU - Scola, Letizia
AU - Crivello, Antonio
AU - Corazza, G. R.
AU - Catassi, C.
AU - Fabiani, E.
AU - Baldassarre, M.
AU - Corvaglia, L.
AU - Spina, M.
AU - Pensabene, L.
AU - Brusa, S.
AU - Gentile, T.
AU - Barera, G.
AU - Bianchi, C.
AU - Rea, F.
AU - Trippiedi, M. A.
AU - Greco, P.
AU - Di Sabatino, A.
AU - Pelli, A. M.
AU - Bonamico, M.
AU - Barbato, M.
AU - Viola, F.
AU - Thanasi, E.
AU - Ambruzzi, A. M.
AU - D'Altilia, M. R.
AU - Musumeci, S.
AU - Barbera, C.
AU - Bramante, L.
AU - Sategna-Guidetti, C.
AU - Martellossi, [No Value]
AU - Ventura, A.
PY - 2003/8
Y1 - 2003/8
N2 - Celiac disease (CD) and selective IgA deficiency (IgAD) are frequently associated, and share the same genetic background. The aim of the present study was to evaluate both Type 1 and 2 plasma cytokine levels in CD and in CD-IgAD. IL-2, TNF-α, IL-10, IL-4 and IL-13 plasma levels were measured both at diagnosis and after a gluten-free diet (GFD) in 32 CD patients, in 27 CD-IgAD patients and in 30 healthy controls. IFN-γ levels were significantly higher in CD and CD-IgAD than in controls, TNF-α displayed significantly higher levels in CD-IgAD when compared both with controls and with CD, and IL-2 was in CD-IgAD significantly increased respect to controls. Kinetics of the Type 1 cytokine plasma levels did not show a clear relationship with the GFD in both groups of CD patients, and particularly in those with IgAD. IL-4 and IL-13, both at diagnosis and after a GFD, were not significantly different in controls and in celiac patients (with and without IgAD). IL-10, whose production is stimulated by the TNF-α, had significantly higher plasma levels in CD-IgAD, but not in CD patients, with a significant decrease after a GFD. CD and especially CD-IgAD patients display persistently higher pro-inflammatory cytokine levels, suggesting a persistent state of activation of pro-phlogistic signals in CD, particularly when IgAD coexists. Serial measurement of serum IL-10 may be an adjunctive evaluating criterion in the follow-up of CD-IgAD patients.
AB - Celiac disease (CD) and selective IgA deficiency (IgAD) are frequently associated, and share the same genetic background. The aim of the present study was to evaluate both Type 1 and 2 plasma cytokine levels in CD and in CD-IgAD. IL-2, TNF-α, IL-10, IL-4 and IL-13 plasma levels were measured both at diagnosis and after a gluten-free diet (GFD) in 32 CD patients, in 27 CD-IgAD patients and in 30 healthy controls. IFN-γ levels were significantly higher in CD and CD-IgAD than in controls, TNF-α displayed significantly higher levels in CD-IgAD when compared both with controls and with CD, and IL-2 was in CD-IgAD significantly increased respect to controls. Kinetics of the Type 1 cytokine plasma levels did not show a clear relationship with the GFD in both groups of CD patients, and particularly in those with IgAD. IL-4 and IL-13, both at diagnosis and after a GFD, were not significantly different in controls and in celiac patients (with and without IgAD). IL-10, whose production is stimulated by the TNF-α, had significantly higher plasma levels in CD-IgAD, but not in CD patients, with a significant decrease after a GFD. CD and especially CD-IgAD patients display persistently higher pro-inflammatory cytokine levels, suggesting a persistent state of activation of pro-phlogistic signals in CD, particularly when IgAD coexists. Serial measurement of serum IL-10 may be an adjunctive evaluating criterion in the follow-up of CD-IgAD patients.
KW - Celiac disease
KW - Cytokine plasma levels, selective IgA deficiency
UR - http://www.scopus.com/inward/record.url?scp=10744231088&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=10744231088&partnerID=8YFLogxK
U2 - 10.1034/j.1399-3038.2003.00053.x
DO - 10.1034/j.1399-3038.2003.00053.x
M3 - Article
C2 - 12911513
AN - SCOPUS:10744231088
VL - 14
SP - 320
EP - 324
JO - Pediatric Allergy and Immunology
JF - Pediatric Allergy and Immunology
SN - 0905-6157
IS - 4
ER -