Plasma elaidic acid level as biomarker of industrial trans fatty acids and risk of weight change: Report from the EPIC study

Véronique Chajès, Carine Biessy, Pietro Ferrari, Isabelle Romieu, Heinz Freisling, Inge Huybrechts, Augustin Scalbert, Bas Bueno De Mesquita, Dora Romaguera, Marc J. Gunter, Paolo Vineis, Camilla Plambeck Hansen, Marianne Uhre Jakobsen, Franc¸oise Clavel-Chapelon, Guy Fagherazzi, Marie Christine Boutron-Ruault, Verana Katzke, Jasmine Neamat-Allah, Heiner Boeing, Ursula BachlechnerAntonia Trichopoulou, Androniki Naska, Philippos Orfanos, Valeria Pala, Giovanna Masala, Amalia Mattiello, Guri Skeie, Elisabete Weiderpass, Antonio Agudo, Jose Maria Huerta, Eva Ardanaz, Maria Jose Sánchez, Miren Dorronsoro, Jose Ramon Quirós, Ingegerd Johansson, Anna Winkvist, Emily Sonested, Tim Key, Kay Tee Khaw, Nicolas J. Wareham, Petra H M Peeters, Nadia Slimani

Research output: Contribution to journalArticlepeer-review


Background: Few epidemiological studies have examined the association between dietary trans fatty acids and weight gain, and the evidence remains inconsistent. The main objective of the study was to investigate the prospective association between biomarker of industrial trans fatty acids and change in weight within the large study European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Methods: Baseline plasma fatty acid concentrations were determined in a representative EPIC sample from the 23 participating EPIC centers. A total of 1,945 individuals were followed for a median of 4.9 years to monitor weight change. The association between elaidic acid level and percent change of weight was investigated using a multinomial logistic regression model, adjusted by length of follow-up, age, energy, alcohol, smoking status, physical activity, and region. Results: In women, doubling elaidic acid was associated with a decreased risk of weight loss (odds ratio (OR) = 0.69, 95% confidence interval (CI) = 0.55-0.88, p = 0.002) and a trend was observed with an increased risk of weight gain during the 5-year follow-up (OR = 1.23, 95% CI = 0.97-1.56, p = 0.082) (p-trend

Original languageEnglish
Article numbere0118206
JournalPLoS One
Issue number2
Publication statusPublished - Feb 12 2015

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)


Dive into the research topics of 'Plasma elaidic acid level as biomarker of industrial trans fatty acids and risk of weight change: Report from the EPIC study'. Together they form a unique fingerprint.

Cite this