There is increasing evidence from in vitro and animal studies that endothelin-1 (ET-1) plays a relevant role in a number of pathophysiological conditions; yet such a role is usually attributed to the locally generated ET-1 rather than to the circulating peptide. However there are several cardiovascular diseases in which plasma levels of ET-1 may reach concentrations high enough to function as classical hormones. In these conditions which include common disorders such as myocardial infarction, congestive heart failure and pulmonary hypertension, the measurement of plasma ET-1 may be clinically useful both for prognostic and therapeutic purposes.
|Journal||Journal of Hypertension, Supplement|
|Publication status||Published - 1998|
- Heart failure
- Pulmonary hypertension
ASJC Scopus subject areas
- Internal Medicine