Endothelin-1 (ET-1), a vasoconstrictor and mitogenic endothelium-derived peptide, has been considered as a marker for endothelial damage and potential contributor to the development of the atherogenic process. Methods. To evaluate the pattern of plasma ET-1 secretion in non-insulin-dependent diabetes mellitus (NIDDM) and nondiabetic patients with chronic arterial obstructive disease (CAOD) of the lower limbs, plasma levels of ET-1 were determined in 12 NIDDM patients (10 men and 2 women; mean age 63 ± 8 years) with CAOD of the lower limbs at Fontaine stage II and in 12 nondiabetic patients (11 men and 1 woman; mean age 62 ± 4 years) with comparable arteriopathy. Ten normal subjects comprised the control population. Results. The plasma levels of ET-1 in NIDDM patients with CAOD of the lower limbs were 5.7 ± 0.3 pmol/L, which represented a significant (p <0.001) difference from the values in nondiabetic patients with comparable arteriopathy (4.1 ± 0.6 pmol/L) and those in the control group (2.7 ± 0.7 pmol/L). Plasma levels of ET-1 showed a significant (p <0.0001) positive correlation with the levels of fasting insulin in NIDDM patients with CAOD of the lower limbs. Increased plasma ET-1 could reflect a major and/or more diffuse endothelial cell damage or dysfunction in NIDDM than in nondiabetic patients with comparable CAOD of the lower limbs. Augmented mitogenic ET-1 levels could also have a role both in diabetic and nondiabetic angiopathy. Conclusions. The positive correlation between ET-1 plasma levels and fasting insulin levels in NIDDM patients with CAOD of the lower limbs suggests that the increased ET-1 release could be related to the augmented insulin secretion in these patients. Insulin-related overproduction of ET-1 could promote the atherogenic process and enhance the vascular tone to a greater extent in NIDDM than in nondiabetic patients with CAOD of the lower limbs.
|Number of pages||6|
|Publication status||Published - Jun 1998|
- Arterial occlusive diseases
- Chronic diseases
- Diabetes mellitus, non insulin dependent
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine