Plasma endothelin-1 release in normal and varicose saphenous veins

Roberto Antonio Mangiafico, Lorenzo Salvatore Malatino, Maurizio Santonocito, Rosario Sebastiano Spada, Francesco Antonio Benedetto

Research output: Contribution to journalArticlepeer-review


The aim of the study was to investigate the release of endothelin-1 (ET- 1) in normal and varicose saphenous veins at baseline and after venous stasis test. Ten patients (eight women and two men, mean age 43 ±4) with primarily varicose great saphenous veins and ten controls (eight women and two men, mean age 42 ±6) were recruited. After 30 minutes of resting in supine position, venous occlusion in a leg was performed with a sphygmomanometer provided to keep the pressure in the cuff intermediate between systolic and diastolic blood pressure for 10 minutes. Blood samples were taken from the great saphenous vein just above the medial malleolus at baseline and 10 minutes after venous stasis was begun. Plasma ET-1 was determined by a radioimmunoassay system. Results are expressed as mean ±SD. Plasma ET-1 concentration was higher in varicose than in normal saphenous veins (4 ±0.1 pmol/L vs 2.6 ±0.1 pmol/L, P

Original languageEnglish
Pages (from-to)769-774
Number of pages6
Issue number9
Publication statusPublished - Sep 1997

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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