Numerous factors are involved in kidney damage, but light chains per se seem to play the dominant role, as suggested by clinical, experimental and morphological studies. In recent years plasma exchange (PE) has been considered the only therapeutic measure capable of achieving a rapid and significant decrease in serum light chain concentration. It has been recommended in the treatment of severe myeloma nephropathy together with forced alkaline diuresis, dialysis and chemotherapy. In this paper, in order to evaluate the effectiveness of PE in the treatment of myeloma nephropathy, the authors studied 15 patients, all affected by severe and rapidly progressive renal failure due to light chain myeloma (LCM). The study results are reported in the paper.
|Title of host publication||Transactions - American Society for Artificial Internal Organs|
|Number of pages||4|
|Publication status||Published - 1984|
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